The Roles of Circular RNAs in Ischemic Stroke through Modulating Neuroinflammation

Ischemic stroke (IS) remains a serious threat to human health. Neuroinflammatory response is an important pathophysiological process after IS. Circular RNAs (circRNAs), a member of the non-coding RNA family, are highly expressed in the central nervous system and widely involved in regulating physiol...

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Bibliographic Details
Published in:Journal of integrative neuroscience 2024-04, Vol.23 (4), p.87-87
Main Authors: Gu, Xin, Li, Lingfei, Chen, Biao, Zhang, Yuyao, Zhou, Yongji, Liu, Keqin, Xia, Wenqin, Li, Xiaoqin, Zhang, Zheng, Shi, Huanqing, Huang, Jinyu, Gao, Beibei, Jiang, Lin, Shao, Anwen, Yin, Congguo
Format: Article
Language:English
Subjects:
Animals
Brain Ischemia - metabolism
circrna
Humans
inflammatory cytokine
ischemic stroke
Ischemic Stroke - genetics
Ischemic Stroke - metabolism
neuroinflammation
Neuroinflammatory Diseases - metabolism
RNA, Circular - metabolism
therapeutic target
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Summary:Ischemic stroke (IS) remains a serious threat to human health. Neuroinflammatory response is an important pathophysiological process after IS. Circular RNAs (circRNAs), a member of the non-coding RNA family, are highly expressed in the central nervous system and widely involved in regulating physiological and pathophysiological processes. This study reviews the current evidence on neuroinflammatory responses, the role of circRNAs in IS and their potential mechanisms in regulating inflammatory cells, and inflammatory factors affecting IS damage. This review lays a foundation for future clinical application of circRNAs as novel biomarkers and therapeutic targets.
ISSN:0219-6352
1757-448X
DOI:10.31083/j.jin2304087