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Study of the Effect of Baicalin from Scutellaria baicalensis on the Gastrointestinal Tract Normoflora and Helicobacter pylori
The antimicrobial properties of baicalin against and several probiotic cultures were evaluated. Baicalin was isolated from a dry plant extract obtained by extraction with water at 70 °C. For isolation, extraction was carried out with n-butanol and purification on a chromatographic column. The antimi...
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| Published in: | International journal of molecular sciences 2023-07, Vol.24 (15), p.11906 |
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| cites | cdi_FETCH-LOGICAL-c482t-39be35869019930f5bee17282bb6cd8e61bd5b47cb4f788bb0b34a7fc93d48d93 |
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| container_issue | 15 |
| container_start_page | 11906 |
| container_title | International journal of molecular sciences |
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| creator | Dmitrieva, Anastasia Kozlova, Oksana Atuchin, Victor Milentieva, Irina Vesnina, Anna Ivanova, Svetlana Asyakina, Lyudmila Prosekov, Alexander |
| description | The antimicrobial properties of baicalin against
and several probiotic cultures were evaluated. Baicalin was isolated from a dry plant extract obtained by extraction with water at 70 °C. For isolation, extraction was carried out with n-butanol and purification on a chromatographic column. The antimicrobial potential was assessed by evaluating changes in the optical density of the bacterial suspension during cultivation; additionally, the disk diffusion method was used. During the study, the baicalin concentrations (0.25, 0.5, and 1 mg/mL) and the pH of the medium in the range of 1.5-8.0 were tested. The test objects were: suspensions of
,
,
,
, and
. It was found that the greater the concentration of the substance in the solution, the greater the delay in the growth of the strain zone. Thus, the highest antimicrobial activity against
was observed at pH 1.5-2.0 and a baicalin concentration of 1.00 mg/mL. In relation to probiotic strains, a stimulating effect of baicalin (1.00 mg/mL) on the growth of
biomass at pH 1.5-2.0 was observed. The results open up the prospects for the use of baicalin and probiotics for the treatment of diseases caused by
. |
| doi_str_mv | 10.3390/ijms241511906 |
| format | article |
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and several probiotic cultures were evaluated. Baicalin was isolated from a dry plant extract obtained by extraction with water at 70 °C. For isolation, extraction was carried out with n-butanol and purification on a chromatographic column. The antimicrobial potential was assessed by evaluating changes in the optical density of the bacterial suspension during cultivation; additionally, the disk diffusion method was used. During the study, the baicalin concentrations (0.25, 0.5, and 1 mg/mL) and the pH of the medium in the range of 1.5-8.0 were tested. The test objects were: suspensions of
,
,
,
, and
. It was found that the greater the concentration of the substance in the solution, the greater the delay in the growth of the strain zone. Thus, the highest antimicrobial activity against
was observed at pH 1.5-2.0 and a baicalin concentration of 1.00 mg/mL. In relation to probiotic strains, a stimulating effect of baicalin (1.00 mg/mL) on the growth of
biomass at pH 1.5-2.0 was observed. The results open up the prospects for the use of baicalin and probiotics for the treatment of diseases caused by
.</description><identifier>ISSN: 1422-0067</identifier><identifier>ISSN: 1661-6596</identifier><identifier>EISSN: 1422-0067</identifier><identifier>DOI: 10.3390/ijms241511906</identifier><identifier>PMID: 37569279</identifier><language>eng</language><publisher>Switzerland: MDPI AG</publisher><subject>Antibiotics ; antimicrobial activity ; Antimicrobial agents ; baicalin ; Consumers ; Ethanol ; Fatty acids ; Flavonoids ; Genes ; Helicobacter pylori ; Herbal medicine ; lactic acid bacteria ; Microbiota ; Microorganisms ; Peptides ; Prebiotics ; Probiotics ; Scutellaria baicalensis ; symbiosis ; Virulence</subject><ispartof>International journal of molecular sciences, 2023-07, Vol.24 (15), p.11906</ispartof><rights>2023 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2023 by the authors. 2023</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c482t-39be35869019930f5bee17282bb6cd8e61bd5b47cb4f788bb0b34a7fc93d48d93</citedby><cites>FETCH-LOGICAL-c482t-39be35869019930f5bee17282bb6cd8e61bd5b47cb4f788bb0b34a7fc93d48d93</cites><orcidid>0000-0002-5630-3196 ; 0000-0002-1252-9572 ; 0000-0003-4988-8197 ; 0000-0002-7424-5604 ; 0000-0002-4552-7418</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.proquest.com/docview/2849061625?pq-origsite=primo$$EPDF$$P50$$Gproquest$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.proquest.com/docview/2849061625?pq-origsite=primo$$EHTML$$P50$$Gproquest$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,25753,27924,27925,37012,37013,38516,43895,44590,53791,53793,74412,75126</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/37569279$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Dmitrieva, Anastasia</creatorcontrib><creatorcontrib>Kozlova, Oksana</creatorcontrib><creatorcontrib>Atuchin, Victor</creatorcontrib><creatorcontrib>Milentieva, Irina</creatorcontrib><creatorcontrib>Vesnina, Anna</creatorcontrib><creatorcontrib>Ivanova, Svetlana</creatorcontrib><creatorcontrib>Asyakina, Lyudmila</creatorcontrib><creatorcontrib>Prosekov, Alexander</creatorcontrib><title>Study of the Effect of Baicalin from Scutellaria baicalensis on the Gastrointestinal Tract Normoflora and Helicobacter pylori</title><title>International journal of molecular sciences</title><addtitle>Int J Mol Sci</addtitle><description>The antimicrobial properties of baicalin against
and several probiotic cultures were evaluated. Baicalin was isolated from a dry plant extract obtained by extraction with water at 70 °C. For isolation, extraction was carried out with n-butanol and purification on a chromatographic column. The antimicrobial potential was assessed by evaluating changes in the optical density of the bacterial suspension during cultivation; additionally, the disk diffusion method was used. During the study, the baicalin concentrations (0.25, 0.5, and 1 mg/mL) and the pH of the medium in the range of 1.5-8.0 were tested. The test objects were: suspensions of
,
,
,
, and
. It was found that the greater the concentration of the substance in the solution, the greater the delay in the growth of the strain zone. Thus, the highest antimicrobial activity against
was observed at pH 1.5-2.0 and a baicalin concentration of 1.00 mg/mL. In relation to probiotic strains, a stimulating effect of baicalin (1.00 mg/mL) on the growth of
biomass at pH 1.5-2.0 was observed. The results open up the prospects for the use of baicalin and probiotics for the treatment of diseases caused by
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and several probiotic cultures were evaluated. Baicalin was isolated from a dry plant extract obtained by extraction with water at 70 °C. For isolation, extraction was carried out with n-butanol and purification on a chromatographic column. The antimicrobial potential was assessed by evaluating changes in the optical density of the bacterial suspension during cultivation; additionally, the disk diffusion method was used. During the study, the baicalin concentrations (0.25, 0.5, and 1 mg/mL) and the pH of the medium in the range of 1.5-8.0 were tested. The test objects were: suspensions of
,
,
,
, and
. It was found that the greater the concentration of the substance in the solution, the greater the delay in the growth of the strain zone. Thus, the highest antimicrobial activity against
was observed at pH 1.5-2.0 and a baicalin concentration of 1.00 mg/mL. In relation to probiotic strains, a stimulating effect of baicalin (1.00 mg/mL) on the growth of
biomass at pH 1.5-2.0 was observed. The results open up the prospects for the use of baicalin and probiotics for the treatment of diseases caused by
.</abstract><cop>Switzerland</cop><pub>MDPI AG</pub><pmid>37569279</pmid><doi>10.3390/ijms241511906</doi><orcidid>https://orcid.org/0000-0002-5630-3196</orcidid><orcidid>https://orcid.org/0000-0002-1252-9572</orcidid><orcidid>https://orcid.org/0000-0003-4988-8197</orcidid><orcidid>https://orcid.org/0000-0002-7424-5604</orcidid><orcidid>https://orcid.org/0000-0002-4552-7418</orcidid><oa>free_for_read</oa></addata></record> |
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| ispartof | International journal of molecular sciences, 2023-07, Vol.24 (15), p.11906 |
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| source | PubMed Central database; Coronavirus Research Database; ProQuest Publicly Available Content database |
| subjects | Antibiotics antimicrobial activity Antimicrobial agents baicalin Consumers Ethanol Fatty acids Flavonoids Genes Helicobacter pylori Herbal medicine lactic acid bacteria Microbiota Microorganisms Peptides Prebiotics Probiotics Scutellaria baicalensis symbiosis Virulence |
| title | Study of the Effect of Baicalin from Scutellaria baicalensis on the Gastrointestinal Tract Normoflora and Helicobacter pylori |
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