Non ictal onset zone: A window to ictal dynamics

Abstract The focal and network concepts of epilepsy present different aspects of electroclinical phenomenon of seizures. Here, we present a 23-year-old man undergoing surgical evaluation with left fronto-temporal electrocorticography (ECoG) and microelectrode-array (MEA) in the middle temporal gyrus...

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Bibliographic Details
Published in:Epilepsy & behavior case reports 2017-01, Vol.8 (C), p.123-127
Main Authors: Afra, Pegah, Hanrahan, Sara J, Kellis, Spencer Sterling, House, Paul
Format: Article
Language:English
Subjects:
Ictal dynamics
Ictal onset
Microelectrode array
Microgrid
Neurology
Single neuron recording
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Summary:Abstract The focal and network concepts of epilepsy present different aspects of electroclinical phenomenon of seizures. Here, we present a 23-year-old man undergoing surgical evaluation with left fronto-temporal electrocorticography (ECoG) and microelectrode-array (MEA) in the middle temporal gyrus (MTG). We compare action-potential (AP) and local field potentials (LFP) recorded from MEA with ECoG. Seizure onset in the mesial-temporal lobe was characterized by changes in the pattern of AP-firing without clear changes in LFP or ECoG in MTG. This suggests simultaneous analysis of neuronal activity in differing spatial scales and frequency ranges provide complementary insights into how focal and network neurophysiological activity contribute to ictal activity.
ISSN:2213-3232
2213-3232
DOI:10.1016/j.ebcr.2017.10.003