Catalyst-Free Synthesis of 2,4-Disubstituted‑1H‑imidazoles through [3 + 2] Cyclization of Vinyl Azides with Amidines

A facile and efficient route for the synthesis of 2,4-disubstituted imidazoles from benzimidamides and vinyl azides through [3 + 2] cyclization under catalyst-free conditions has been described. The method is compatible for a broad range of functional groups with good to excellent yields.

Saved in:
Bibliographic Details
Published in:ACS omega 2017-08, Vol.2 (8), p.5235-5241
Main Authors: Reddy, N. Naresh Kumar, Nageswara Rao, Sadu, Ravi, Chitrakar, Adimurthy, Subbarayappa
Format: Article
Language:English
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:A facile and efficient route for the synthesis of 2,4-disubstituted imidazoles from benzimidamides and vinyl azides through [3 + 2] cyclization under catalyst-free conditions has been described. The method is compatible for a broad range of functional groups with good to excellent yields.
ISSN:2470-1343
2470-1343
DOI:10.1021/acsomega.7b00969