Group VIII Metal Carbonyl Cluster-Boronic Acid Conjugates: Cytotoxicity and Mode of Action Studies

A set of metal carbonyl cluster-boronic acid conjugates of the group VIII metals (Fe, Ru, and Os) were synthesized and their antiproliferative effects measured against two breast cancer cell lines (MCF-7 and MDA-MB-231) and a noncancerous breast epithelial (MCF-10A) cell line. The cytotoxicity follo...

Full description

Saved in:
Bibliographic Details
Published in:ACS omega 2021-11, Vol.6 (43), p.29045-29053
Main Authors: Kong, Jia Wen, Lam, Zhiyong, Chan, Kiat Hwa, Ganguly, Rakesh, Joey Lee, Jia-Ying, Loo, Lit-Hsin, Webster, Richard D, Wong, Zhen Xuan, Leong, Weng Kee
Format: Article
Language:English
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:A set of metal carbonyl cluster-boronic acid conjugates of the group VIII metals (Fe, Ru, and Os) were synthesized and their antiproliferative effects measured against two breast cancer cell lines (MCF-7 and MDA-MB-231) and a noncancerous breast epithelial (MCF-10A) cell line. The cytotoxicity followed the order Ru > Os > Fe for the MDA-MB-231 cells, although the latter two exhibited similar cytotoxicity against MCF-7 and MCF-10A cells. The osmium species {Os3(CO)10(μ-H)­[μ-SC6H4-p-B­(OH)2]} (2) could be chemically oxidized to its hydroxy analogue [Os3(CO)10(μ-H)­(μ-SC6H4 -p-OH)] (2-OH), which showed comparable cytotoxicity. Mode of action studies pointed to an apoptotic pathway for cell death.
ISSN:2470-1343
2470-1343
DOI:10.1021/acsomega.1c04116