15O-water PET for evaluation of cardiopulmonary perfusion in complex cyanotic heart disease

Background Dynamic 15 O-water PET may provide information about cardiopulmonary circulation complementary to MRI and CT in complex cyanotic heart disease. Case presentation We present a case in which a 15 O-water PET scan was used for the first time to map the complex circulation in a univentricular...

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Bibliographic Details
Published in:European journal of hybrid imaging 2020-02, Vol.4 (1), p.3-3, Article 3
Main Authors: Madsen, S., Tolbod, L. P., Mortensen, U. M., Andersen, G., Bouchelouche, K.
Format: Article
Language:English
Subjects:
15O-water PET
Anastomosis
Blood
Blood circulation
Cardiovascular disease
Cardiovascular diseases
Case Report
Congenital heart disease
Coronary artery disease
Cyanosis
Heart
Heart diseases
Heart transplantation
Imaging
Lung perfusion
Lungs
Magnetic resonance imaging
Medicine
Medicine & Public Health
Myocardial blood flow
Nuclear Medicine
O-15-H2O PET
Perfusion
Positron emission
Pulmonary arteries
Pulmonary artery
Radiology
Tomography
Transit time
Transplantation
Ventricle
Water circulation
Water PET
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Summary:Background Dynamic 15 O-water PET may provide information about cardiopulmonary circulation complementary to MRI and CT in complex cyanotic heart disease. Case presentation We present a case in which a 15 O-water PET scan was used for the first time to map the complex circulation in a univentricular heart patient with dual pulmonary blood supply. The pulmonary blood supply consisted of partially oxygenated blood led from the univentricle to the lungs by the pulmonary artery, plus of venous blood from the upper body lead by a bidirectional Glenn anastomosis to the right pulmonary artery. Despite the bidirectional Glenn anastomosis, the patient developed increasing cyanosis and was considered for heart transplantation. Pulmonary perfusion measurements using MRI were inconclusive due to metal artifacts, and the patient was referred for a 15 O-water PET scan. The scan showed significant venovenous collaterals bypassing the lungs. Only the left upper lung lobe was properly perfused. The mean transit time from the superior vena cava to the left ventricle was approximately four times longer than would be expected from a healthy person. Conclusion The case illustrates that 15 O-water PET can complement CT and MRI for quantitative characterization of cardiopulmonary circulation in complex cyanotic heart disease.
ISSN:2510-3636
2510-3636
DOI:10.1186/s41824-020-0072-4