Alkylation of N-substituted 2-phenylacetamides: Benzylation of N-(4-chlorophenyl)-2-phenylacetamide

Benzylation of N-(4-chlorophenyl)-2-phenylacetamidewith benzyl chloride in the presence of powdered potassium hydroxide under various reaction conditions was performed in order to establish the possible reaction products. Different temperatures and ratios of reactants and solvents were used. The rea...

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Bibliographic Details
Published in:Journal of the Serbian Chemical Society 2004, Vol.69 (2), p.85-92
Main Authors: Mijin, Dusan, Jankovic, Vida, Petrovic, Slobodan
Format: Article
Language:English
Subjects:
2-phenylacetamides
alkylation
benzylation
phase-transfer catalysis
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Summary:Benzylation of N-(4-chlorophenyl)-2-phenylacetamidewith benzyl chloride in the presence of powdered potassium hydroxide under various reaction conditions was performed in order to establish the possible reaction products. Different temperatures and ratios of reactants and solvents were used. The reactions were also carried out in the presence of different phase-transfer catalysts in toluene as a solvent. The formation of the reaction products was followed using gas chromatography. On the basis of the obtained results, the reactivity and the orientation in the alkylation reaction of the investigated amide is discussed. N-(4-hlorfenil)-2-fenilacetamid je alkilovan benzil-hloridom u razlicitim rastvarac ima u prisustvu sprasenog kalijum-hidroksida na razlicitim temperaturama. Reakcije su izvodjene u prisustvu razlicitih medjufaznih katalizatora kao i bez katalizatora u cilju ispitivanja uticaja reakcionih uslova na reaktivnost i orijentaciju reakcije alkilovanja ispitivanog jedinjenja.
ISSN:0352-5139
1820-7421
DOI:10.2298/JSC0402085M