Quercetin-loaded on whey protein improves male fertility parameters and atherogenic indices of rats on a western-style diet

[Display omitted] •A western-style diet increases the testicular cells apoptosis and abnormality.•High fat-high fructose intake induces spermatogenesis and sperm motility alterations.•Quercetin loaded on whey protein is a new antioxidant-therapy for male infertility.•Atherogenic indices reached near...

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Bibliographic Details
Published in:Journal of functional foods 2022-01, Vol.88, p.104904, Article 104904
Main Authors: Mousavi, Seyedeh Neda, Seyed Dorraji, Mir Saeed, Pourmansouri, Zeinab, Mohammadian, Masoud, Chiti, Hossein, Moghaddam, Naiemeh, Hosseini, Elham
Format: Article
Language:English
Subjects:
Atherogenic indices
Male fertility
Protein-gel
Quercetin
Western-style diet
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Summary:[Display omitted] •A western-style diet increases the testicular cells apoptosis and abnormality.•High fat-high fructose intake induces spermatogenesis and sperm motility alterations.•Quercetin loaded on whey protein is a new antioxidant-therapy for male infertility.•Atherogenic indices reached near to the control in the Pro-gel-Quer-treated one. The western-style diet, characterized by high fat-high fructose (HF/HFr) intake, induces alteration in spermatogenesis and testicular functions by atherogenic indices derangement and oxidative stress. The antioxidant properties of Quercetin (Quer) are proved; however, it has some adverse effects on male fertility parameters. So, this study aimed to investigate the protective effect of a biocompatible carrier (whey protein coated with black seed oil) as a new drug delivery system to encapsulate the Quer on atherogenic indices, insulin sensitivity, sperm parameters, and testicular function alterations induced by a western-style diet in male rats. Abnormal testicular epithelium with detached and swelled germ cells, alterations in the ratio of the spermatogenic cells, increased percentage of apoptotic cells (TUNEL-positive), and abnormalities in sperm parameters were observed in the male rats on a western-style diet. Treated groups with the free Pro-gel (whey protein gel) and Pro-gel-Quer (Quer loaded on whey protein gel) showed significant recovery of the germ cells and reduction in the TUNEL-positive cell number. There was a significant increase in the atherogenic index TG/HDL-C, serum FBS, insulin, and HOMA-IR, but the decrease in testosterone levels in the model groups (p 
ISSN:1756-4646
2214-9414
DOI:10.1016/j.jff.2021.104904