Electrospun Nanofibers Encapsulated with Natural Products: A Novel Strategy to Counteract Skin Aging

The skin is the primary tissue affected by wounds and aging, significantly impacting its protective function. Natural products are widely used in cosmetics, representing a new approach to preventing age-related damage. Nanomedicine combines nanotechnology and traditional treatments to create innovat...

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Bibliographic Details
Published in:International journal of molecular sciences 2024-02, Vol.25 (3), p.1908
Main Authors: Serra, Diletta, Garroni, Giuseppe, Cruciani, Sara, Coradduzza, Donatella, Pashchenko, Aleksei, Amler, Evzen, Pintore, Giorgio, Satta, Rosanna, Montesu, Maria Antonietta, Kohl, Yvonne, Ventura, Carlo, Maioli, Margherita
Format: Article
Language:English
Subjects:
Aging
Antioxidants
bioactive molecules
Biocompatibility
Biological Products - pharmacology
Care and treatment
Cell division
Cosmetics
Fibroblasts
Gene expression
Helichrysum italicum
Humans
molecular mechanisms
Nanofibers
Oils & fats
Pharmaceuticals
Polymers
Polyvinyl Alcohol
Radiation
Senescence
Skin
Skin Aging
Stem cells
Telomerase
Wound Healing
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Summary:The skin is the primary tissue affected by wounds and aging, significantly impacting its protective function. Natural products are widely used in cosmetics, representing a new approach to preventing age-related damage. Nanomedicine combines nanotechnology and traditional treatments to create innovative drugs. The main targets of nanotechnological approaches are wound healing, regeneration, and rejuvenation of skin tissue. The skin barrier is not easily permeable, and the creation of modern nanodevices is a way to improve the passive penetration of substances. In this study, oil ( ) was combined with different types of electrospun nanofibers to study their protective activity on the skin and to evaluate their future application for topical treatments. In the present research, we used biodegradable polymers, including polyvinyl alcohol (PVA) and polyvinylpyrrolidone (PVP), which were characterized by a scanning electron microscope (SEM). All results show a positive trend in cell proliferation and viability of human skin stem cells (SSCs) and BJ fibroblasts pre-treated with combined nanofibers and then exposed to UV stress. Gene expression analysis revealed the activation of a molecular rejuvenation program in SSCs treated with functionalized nanofibers before UV exposure. Understanding the mechanisms involved in skin changes during aging allows for the future application of nanomaterials combined with directly to the patients.
ISSN:1422-0067
1661-6596
1422-0067
DOI:10.3390/ijms25031908