Origanum vulgare L. essential oil inhibits the growth of carbapenem-resistant gram-negative bacteria

Plant products are sources for drug development against multidrug resistant bacteria. The antimicrobial activity of Origanum vulgare L. essential oil (OVeo) against carbapenem-resistant strains was assessed by disk-diffusion, microdilution (REMA-Resazurin Microtiter Assay), and time kill assays. Car...

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Bibliographic Details
Published in:Revista da Sociedade Brasileira de Medicina Tropical 2019-01, Vol.52, p.e20180502-e20180502
Main Authors: Vasconcelos, Nathalie Gaebler, Croda, Júlio, Silva, Késia Esther, Motta, Maria Lorenza Leal, Maciel, Wirlaine Glauce, Limiere, Letícia Cristina, Simionatto, Simone
Format: Article
Language:English
Subjects:
Acinetobacter baumannii - drug effects
Acinetobacter baumannii - growth & development
Anti-Bacterial Agents - classification
Anti-Bacterial Agents - pharmacology
Antimicrobial activity
Bacterial Proteins
beta-Lactamases
Carbapenemase
Carbapenems - pharmacology
Drug Resistance, Multiple, Bacterial
Gram-Negative Bacteria - drug effects
Gram-Negative Bacteria - growth & development
Humans
Klebsiella pneumoniae - drug effects
Klebsiella pneumoniae - growth & development
Microbial Sensitivity Tests
Multidrug resistance
Oils, Volatile - pharmacology
Oregano
Origanum - chemistry
Serratia marcescens - drug effects
Serratia marcescens - growth & development
TROPICAL MEDICINE
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Summary:Plant products are sources for drug development against multidrug resistant bacteria. The antimicrobial activity of Origanum vulgare L. essential oil (OVeo) against carbapenem-resistant strains was assessed by disk-diffusion, microdilution (REMA-Resazurin Microtiter Assay), and time kill assays. Carbapenemase production was confirmed for all strains. OVeo exhibited a minimum inhibitory concentration of 0.059% v/v for Klebsiella pneumoniae and Serratia marcescens, and of 0.015 % v/v for Acinetobacter baumannii. A decrease in cell count was observed after a 4 h treatment. OVeo antimicrobial effect was rapid and consistent, making it a candidate for developing alternative therapeutic options against carbapenem-resistant strains.
ISSN:0037-8682
1678-9849
1678-9849
DOI:10.1590/0037-8682-0502-2018