Metabolomic Signature of Coronary Artery Disease in Type 2 Diabetes Mellitus

Coronary artery disease (CAD) is a common complication of type 2 diabetes mellitus (T2D). This case-control study was done to identify metabolites with different concentrations between T2D patients with and without CAD and to characterise implicated metabolic mechanisms relating to CAD. Fasting seru...

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Bibliographic Details
Published in:International Journal of Endocrinology 2017-01, Vol.2017 (2017), p.1-9
Main Authors: Wang-Sattler, Rui, Tschoepe, Diethelm, Adamski, Jerzy, Prehn, Cornelia, Xu, Tao, Yu, Zhonghao, Wang, Ruichao, Richter, Katrin, Stratmann, Bernd, Illig, Thomas
Format: Article
Language:English
Subjects:
Amino acids
Antilipemic agents
Biomarkers
Blood pressure
Cardiac stress tests
Cardiovascular disease
Cholesterol
Coronary heart disease
Coronary vessels
Diabetes
Discriminant analysis
Dosage and administration
Endocrinology
Hyperglycemia
Insulin resistance
Metabolism
Metabolites
Peptides
Risk factors
Signal transduction
Studies
Type 2 diabetes
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Summary:Coronary artery disease (CAD) is a common complication of type 2 diabetes mellitus (T2D). This case-control study was done to identify metabolites with different concentrations between T2D patients with and without CAD and to characterise implicated metabolic mechanisms relating to CAD. Fasting serum samples of 57 T2D subjects, 26 with (cases) and 31 without CAD (controls), were targeted for metabolite profiling of 163 metabolites. To assess the association between metabolite levels and CAD, partial least squares (PLS) analysis and multivariate logistic regression analysis with adjustment for CAD risk factors and medications were performed. We observed a separation of cases and controls with two classes of metabolites being significantly associated with CAD, including phosphatidylcholines, and serine. Four metabolites being independent from the common CAD risk factors displaying best separation between cases and controls were further selected. Addition of the metabolite concentrations to risk factor analysis raised the area under the receiver-operating-characteristic curve from 0.72 to 0.88 (p=0.020), providing improved sensitivity and specificity for CAD classification. Serum phospholipid and serine levels independently discriminate T2D patients with and without CAD. Oxidative stress and reduced antioxidative capacity lead to lower metabolite concentrations probably due to changes in membrane composition and accelerated phospholipid degradation.
ISSN:1687-8337
1687-8345
DOI:10.1155/2017/7938216