Comparison of Rheological, Drug Release, and Mucoadhesive Characteristics upon Storage between Hydrogels with Unmodified or Beta-Glycerophosphate-Crosslinked Chitosan

The physicochemical characteristics of beta-glycerophosphate-crosslinked chitosan hydrogels were investigated upon long-term storage at ambient, accelerated, and refrigerated conditions and compared to unmodified chitosan formulations. Additionally, the impact of chitosan modification on the ex vivo...

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Bibliographic Details
Published in:International journal of polymer science 2018-01, Vol.2018 (2018), p.1-12
Main Authors: Szymańska, Emilia, Winnicka, Katarzyna, Czajkowska-Kośnik, Anna
Format: Article
Language:English
Subjects:
Acids
Antimicrobial agents
Chitosan
Crosslinking
Depolymerization
Drug delivery systems
Drug dosages
Formulations
Glycerophosphate
Hydrogels
Mechanical properties
Pharmaceutical sciences
Polymers
Rheological properties
Rheology
Viscosity
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Summary:The physicochemical characteristics of beta-glycerophosphate-crosslinked chitosan hydrogels were investigated upon long-term storage at ambient, accelerated, and refrigerated conditions and compared to unmodified chitosan formulations. Additionally, the impact of chitosan modification on the ex vivo mucoadhesive performance in contact with porcine vaginal mucosa and on the drug release profile from hydrogels was evaluated. Viscosity and mechanical properties of formulations with unmodified chitosan decreased significantly upon storage regardless of tested conditions as a result of hydrolytic depolymerization. Introduction of ion crosslinker exerted stabilizing effect on physicochemical performance of chitosan hydrogels but only upon storage at refrigerated conditions. Beta-glycerophosphate-modified chitosan formulations preserved organoleptic, rheological behavior, and hydrogel structure up to 3-month storage at 4 ± 2°C. Viscosity variations upon storage influenced markedly mucoadhesive properties and drug release rate from hydrogels.
ISSN:1687-9422
1687-9430
DOI:10.1155/2018/3592843