Relapsing Polychondritis: An Updated Review

Relapsing polychondritis is an immune-mediated systemic disease characterized by recurrent episodes of inflammation of cartilaginous and proteoglycan-rich tissues, resulting in progressive anatomical deformation and functional impairment of the involved structures. Auricular and nasal chondritis and...

Full description

Saved in:
Bibliographic Details
Published in:Biomedicines 2018-08, Vol.6 (3), p.84
Main Authors: Borgia, Francesco, Giuffrida, Roberta, Guarneri, Fabrizio, Cannavò, Serafinella P
Format: Article
Language:English
Subjects:
anti-type II collagen antibodies
Arthritis
auricular chondritis
Biological products
Cartilage
Collagen
Extracellular matrix
Immunoglobulins
Literature reviews
Pathogenesis
Patients
Polyarthritis
Polychondritis
Proteins
relapsing polychondritis
Review
Rheumatology
Substance abuse treatment
systemic autoimmune disease
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Relapsing polychondritis is an immune-mediated systemic disease characterized by recurrent episodes of inflammation of cartilaginous and proteoglycan-rich tissues, resulting in progressive anatomical deformation and functional impairment of the involved structures. Auricular and nasal chondritis and/or polyarthritis represent the most common clinical features, but potentially all types of cartilage may be involved. Because of the pleomorphic nature of the disease, with non-specific symptoms at the onset, the diagnosis of relapsing polychondritis is often delayed. In this review article we provide a comprehensive look into clinical presentation, laboratory and instrumental investigations, diagnostic criteria, and therapeutic options.
ISSN:2227-9059
2227-9059
DOI:10.3390/biomedicines6030084