Principles of Zebrafish Nephron Segment Development

Nephrons are the functional units which comprise the kidney. Each nephron contains a number of physiologically unique populations of specialized epithelial cells that are organized into discrete domains known as segments. The principles of nephron segment development have been the subject of many st...

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Bibliographic Details
Published in:Journal of developmental biology 2023-03, Vol.11 (1), p.14
Main Authors: Nguyen, Thanh Khoa, Petrikas, Madeline, Chambers, Brooke E, Wingert, Rebecca A
Format: Article
Language:English
Subjects:
Biomedical research
Congenital defects
Danio rerio
development
Developmental biology
distal tubule
Electrolytes
Epithelial cells
Genetic disorders
Genomes
Kidneys
Mutagenesis
Mutation
nephron
Nephrons
Physiology
Regenerative medicine
Review
segment
Tfap2a
Urinary tract
zebrafish
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Summary:Nephrons are the functional units which comprise the kidney. Each nephron contains a number of physiologically unique populations of specialized epithelial cells that are organized into discrete domains known as segments. The principles of nephron segment development have been the subject of many studies in recent years. Understanding the mechanisms of nephrogenesis has enormous potential to expand our knowledge about the basis of congenital anomalies of the kidney and urinary tract (CAKUT), and to contribute to ongoing regenerative medicine efforts aimed at identifying renal repair mechanisms and generating replacement kidney tissue. The study of the zebrafish embryonic kidney, or pronephros, provides many opportunities to identify the genes and signaling pathways that control nephron segment development. Here, we describe recent advances of nephron segment patterning and differentiation in the zebrafish, with a focus on distal segment formation.
ISSN:2221-3759
2221-3759
DOI:10.3390/jdb11010014