Mechanistic basis and clinical relevance of the role of transforming growth factor-β in cancer

Transforming growth factor-β（TGF-β） is a key factor in cancer development and progression. TGF-β can suppress tumorigenesis by inhibiting cell cycle progression and stimulating apoptosis in early stages of cancer progression. However, TGF-β can modulate cancer-related processes, such as cell invasio...

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Bibliographic Details
Published in:Cancer biology & medicine 2015-12, Vol.12 (4), p.385-393
Main Authors: Lin, Run-Long, Zhao, Lu-Jun
Format: Article
Language:English
Subjects:
Apoptosis
Breast cancer
Cancer
Cell cycle
Cell division
Clinical trials
Esophagus
Growth factors
Kinases
Ligands
Medical prognosis
Mesenchyme
Metastases
Metastasis
Mutation
neoplasms
prognosis
Proteins
Review
TGF-β
therapeutics
Transforming growth factor-b
Transforming growth factor-β (TGF-β)
临床意义
凋亡抑制
早期阶段
机理
细胞浸润
肿瘤发生
转化生长因子β
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Summary:Transforming growth factor-β（TGF-β） is a key factor in cancer development and progression. TGF-β can suppress tumorigenesis by inhibiting cell cycle progression and stimulating apoptosis in early stages of cancer progression. However, TGF-β can modulate cancer-related processes, such as cell invasion, distant metastasis, and microenvironment modification that may be used by cancer cells to their advantage in late stages. Corresponding mechanisms include angiogenesis promotion, anti-tumor immunity suppression, and epithelial-to-mesenchymal transition（EMT） induction. The correlation between TGF-β expression and cancer prognosis has also been extensively investigated. Results suggest that TGF-β pathway can be targeted to treat cancer; as such, the feasibility of this treatment is investigated in clinical trials.
ISSN:2095-3941
2095-3941
DOI:10.7497/j.issn.2095-3941.2015.0015