Prevalence of clinical signs and factors impacting expression of myosin heavy chain myopathy in Quarter Horse‐related breeds with the MYH1E321G mutation

Background The prevalence of clinical signs and factors triggering muscle atrophy and rhabdomyolysis associated with an MYH1E321G mutation in Quarter Horses and related breeds (QH) remain poorly understood. Hypothesis/Objectives Determine the prevalence and potential triggers of atrophy and stiffnes...

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Bibliographic Details
Published in:Journal of veterinary internal medicine 2022-05, Vol.36 (3), p.1152-1159
Main Authors: Valberg, Stephanie J., Schultz, Abigail E., Finno, Carrie J., Bellone, Rebecca R., Hughes, Shayne S.
Format: Article
Language:English
Subjects:
Atrophy
Encephalitis
Enzymes
equine
Gastrointestinal diseases
Genetic disorders
Horses
Hyperthermia
Immunization
Laboratories
muscle
Mutation
Questionnaires
Rhabdomyolysis
Vaccines
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Summary:Background The prevalence of clinical signs and factors triggering muscle atrophy and rhabdomyolysis associated with an MYH1E321G mutation in Quarter Horses and related breeds (QH) remain poorly understood. Hypothesis/Objectives Determine the prevalence and potential triggers of atrophy and stiffness in horses homozygous reference (N/N), heterozygous (My/N), and homozygous (My/My) for the MYH1E321G mutation. Animals Two‐hundred seventy‐five N/N, 100 My/N, and 10 My/My QH. Methods A retrospective case‐control study using a closed‐ended questionnaire completed by clients of the Veterinary Genetics Laboratory at the University of California, Davis. History of clinical signs, disease, vaccination and performance were analyzed by genotype using contingency testing. Results Atrophy occurred in proportionately more horses with MYH1E321G (My) than N/N QH and more frequently in My/My than My/N QH (P 
ISSN:0891-6640
1939-1676
1939-1676
DOI:10.1111/jvim.16417