The Pathology of Intestinal Mucosal Disruption; Implications for Muscle Loss and Physical Dependency from Late Adolescence to Octogenarians

A pathological increase in intestinal permeability causes muscle loss and physical decline by inducing systemic inflammation and oxidative stress. However, most relevant studies investigate older adults, and the appropriate data across age spans remain elusive. This study aimed to examine the associ...

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Bibliographic Details
Published in:International journal of general medicine 2024-01, Vol.17, p.6117-6126
Main Authors: Qaisar, Rizwan, Karim, Asima, Iqbal, M Shahid, Muhammad, Tahir, Ahmad, Firdos, Alkahtani, Shaea A
Format: Article
Language:English
Subjects:
Activities of daily living
Adolescence
Adults
Age groups
Biochemistry
Biomarkers
Body composition
Child development
Gait
gait speed
handgrip strength
Inflammation
intestinal permeability
Kinases
Middle age
Muscle strength
Musculoskeletal system
Older people
Original Research
Oxidative stress
Permeability
Plasma
Research ethics
Sarcopenia
Sedentary behavior
Statistical analysis
Toxins
zonulin
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Summary:A pathological increase in intestinal permeability causes muscle loss and physical decline by inducing systemic inflammation and oxidative stress. However, most relevant studies investigate older adults, and the appropriate data across age spans remain elusive. This study aimed to examine the associations of intestinal permeability with muscle loss and physical decline across a large span of ages. We measured plasma zonulin, a marker of increased intestinal permeability, from adolescents to octogenarians in association with muscle health and gait speed. In this cross-sectional, observational study, we recruited healthy men, including young (age=18-35 years, n=135), middle-aged (age=35-59 years, n=118), and older (age=60-90 years, n=163) adults for evaluating - handgrip strength (HGS), skeletal muscle mass index (SMI), and gait speed. We also measured plasma zonulin, c-reactive proteins (CRP), and 8-isoprostanes using ELISA assays. Plasma zonulin gradually increased from young and middle-aged to older adults (all p
ISSN:1178-7074
1178-7074
DOI:10.2147/IJGM.S501358