Association between a Variant in MicroRNA-646 and the Susceptibility to Hepatocellular Carcinoma in a Large-Scale Population

Background. Single-nucleotide polymorphisms in microRNAs play important roles in oncogenesis and cancer development. Objective. We aim to explore whether miR-646 rs6513497 is associated with the risk of hepatocellular carcinoma. Methods. Total 997 HCC patients and 993 cancer-free controls were enrol...

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Published in:TheScientificWorld 2014-01, Vol.2014 (2014), p.1-7
Main Authors: Liu, Jie, Liu, Yi, Hu, Heping, Jin, Bohan, Li, Wenshuai, Ma, Yanyun, Jiang, Weiru, Zhang, Jun, Wang, Rui, Wang, Jiucun
Format: Article
Language:English
Subjects:
Adult
Aged
Carcinoma, Hepatocellular - genetics
Case-Control Studies
Colorectal cancer
Confidence intervals
Demographic aspects
Deoxyribonucleic acid
Development and progression
DNA
Female
Gene expression
Genetic aspects
Genetic engineering
Genetic variation
Genotype & phenotype
Health aspects
Hepatoma
Hospitals
Humans
Liver cancer
Liver Neoplasms - genetics
Male
Medical imaging
MicroRNA
MicroRNAs
MicroRNAs - genetics
Middle Aged
NMR
Nuclear magnetic resonance
Polymorphism, Single Nucleotide
Population
Risk reduction
Studies
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cited_by cdi_FETCH-LOGICAL-c633t-879797f2c89cd7fbad4bd9e884a5b931b4f0883d45d986d1384770c75bc7bcb13
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creator Liu, Jie
Liu, Yi
Hu, Heping
Jin, Bohan
Li, Wenshuai
Ma, Yanyun
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Zhang, Jun
Wang, Rui
Wang, Jiucun
description Background. Single-nucleotide polymorphisms in microRNAs play important roles in oncogenesis and cancer development. Objective. We aim to explore whether miR-646 rs6513497 is associated with the risk of hepatocellular carcinoma. Methods. Total 997 HCC patients and 993 cancer-free controls were enrolled in this study. Genotyping was performed using MassARRAY method. Results. Compared with the T allele of rs6513497, the G allele was associated with a significantly decreased risk of HCC (OR = 0.788, 95% CI = 0.631–0.985, P = 0.037); moreover, a more protective effect of the G allele was shown in males (OR = 0.695, 95% CI = 0.539–0.897, P = 0.005 in HCC and OR = 0.739, 95% CI = 0.562–0.972, P = 0.030 in HBV-related HCC), basically in a dominant manner (HCC: OR = 0.681, 95% CI = 0.162–0.896, P = 0.006; HBV-related HCC: OR = 0.715, 95% CI = 0.532–0.962, P = 0.027). Conclusions. Our findings support the view that the miR-646 SNP rs6513497 may contribute to the susceptibility of HCC.
doi_str_mv 10.1155/2014/312704
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Single-nucleotide polymorphisms in microRNAs play important roles in oncogenesis and cancer development. Objective. We aim to explore whether miR-646 rs6513497 is associated with the risk of hepatocellular carcinoma. Methods. Total 997 HCC patients and 993 cancer-free controls were enrolled in this study. Genotyping was performed using MassARRAY method. Results. Compared with the T allele of rs6513497, the G allele was associated with a significantly decreased risk of HCC (OR = 0.788, 95% CI = 0.631–0.985, P = 0.037); moreover, a more protective effect of the G allele was shown in males (OR = 0.695, 95% CI = 0.539–0.897, P = 0.005 in HCC and OR = 0.739, 95% CI = 0.562–0.972, P = 0.030 in HBV-related HCC), basically in a dominant manner (HCC: OR = 0.681, 95% CI = 0.162–0.896, P = 0.006; HBV-related HCC: OR = 0.715, 95% CI = 0.532–0.962, P = 0.027). Conclusions. Our findings support the view that the miR-646 SNP rs6513497 may contribute to the susceptibility of HCC.</description><identifier>ISSN: 2356-6140</identifier><identifier>ISSN: 1537-744X</identifier><identifier>EISSN: 1537-744X</identifier><identifier>DOI: 10.1155/2014/312704</identifier><identifier>PMID: 25177719</identifier><language>eng</language><publisher>Cairo, Egypt: Hindawi Publishing Corporation</publisher><subject>Adult ; Aged ; Carcinoma, Hepatocellular - genetics ; Case-Control Studies ; Colorectal cancer ; Confidence intervals ; Demographic aspects ; Deoxyribonucleic acid ; Development and progression ; DNA ; Female ; Gene expression ; Genetic aspects ; Genetic engineering ; Genetic variation ; Genotype &amp; phenotype ; Health aspects ; Hepatoma ; Hospitals ; Humans ; Liver cancer ; Liver Neoplasms - genetics ; Male ; Medical imaging ; MicroRNA ; MicroRNAs ; MicroRNAs - genetics ; Middle Aged ; NMR ; Nuclear magnetic resonance ; Polymorphism, Single Nucleotide ; Population ; Risk reduction ; Studies</subject><ispartof>TheScientificWorld, 2014-01, Vol.2014 (2014), p.1-7</ispartof><rights>Copyright © 2014 Rui Wang et al.</rights><rights>COPYRIGHT 2014 John Wiley &amp; Sons, Inc.</rights><rights>Copyright © 2014 Rui Wang et al. 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This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.</rights><rights>Copyright © 2014 Rui Wang et al. 2014</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c633t-879797f2c89cd7fbad4bd9e884a5b931b4f0883d45d986d1384770c75bc7bcb13</citedby><cites>FETCH-LOGICAL-c633t-879797f2c89cd7fbad4bd9e884a5b931b4f0883d45d986d1384770c75bc7bcb13</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.proquest.com/docview/1553698364/fulltextPDF?pq-origsite=primo$$EPDF$$P50$$Gproquest$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.proquest.com/docview/1553698364?pq-origsite=primo$$EHTML$$P50$$Gproquest$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,25731,27901,27902,36989,36990,44566,53766,53768,74869</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25177719$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Ferracin, Manuela</contributor><creatorcontrib>Liu, Jie</creatorcontrib><creatorcontrib>Liu, Yi</creatorcontrib><creatorcontrib>Hu, Heping</creatorcontrib><creatorcontrib>Jin, Bohan</creatorcontrib><creatorcontrib>Li, Wenshuai</creatorcontrib><creatorcontrib>Ma, Yanyun</creatorcontrib><creatorcontrib>Jiang, Weiru</creatorcontrib><creatorcontrib>Zhang, Jun</creatorcontrib><creatorcontrib>Wang, Rui</creatorcontrib><creatorcontrib>Wang, Jiucun</creatorcontrib><title>Association between a Variant in MicroRNA-646 and the Susceptibility to Hepatocellular Carcinoma in a Large-Scale Population</title><title>TheScientificWorld</title><addtitle>ScientificWorldJournal</addtitle><description>Background. Single-nucleotide polymorphisms in microRNAs play important roles in oncogenesis and cancer development. Objective. We aim to explore whether miR-646 rs6513497 is associated with the risk of hepatocellular carcinoma. Methods. Total 997 HCC patients and 993 cancer-free controls were enrolled in this study. Genotyping was performed using MassARRAY method. Results. Compared with the T allele of rs6513497, the G allele was associated with a significantly decreased risk of HCC (OR = 0.788, 95% CI = 0.631–0.985, P = 0.037); moreover, a more protective effect of the G allele was shown in males (OR = 0.695, 95% CI = 0.539–0.897, P = 0.005 in HCC and OR = 0.739, 95% CI = 0.562–0.972, P = 0.030 in HBV-related HCC), basically in a dominant manner (HCC: OR = 0.681, 95% CI = 0.162–0.896, P = 0.006; HBV-related HCC: OR = 0.715, 95% CI = 0.532–0.962, P = 0.027). Conclusions. 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Single-nucleotide polymorphisms in microRNAs play important roles in oncogenesis and cancer development. Objective. We aim to explore whether miR-646 rs6513497 is associated with the risk of hepatocellular carcinoma. Methods. Total 997 HCC patients and 993 cancer-free controls were enrolled in this study. Genotyping was performed using MassARRAY method. Results. Compared with the T allele of rs6513497, the G allele was associated with a significantly decreased risk of HCC (OR = 0.788, 95% CI = 0.631–0.985, P = 0.037); moreover, a more protective effect of the G allele was shown in males (OR = 0.695, 95% CI = 0.539–0.897, P = 0.005 in HCC and OR = 0.739, 95% CI = 0.562–0.972, P = 0.030 in HBV-related HCC), basically in a dominant manner (HCC: OR = 0.681, 95% CI = 0.162–0.896, P = 0.006; HBV-related HCC: OR = 0.715, 95% CI = 0.532–0.962, P = 0.027). Conclusions. Our findings support the view that the miR-646 SNP rs6513497 may contribute to the susceptibility of HCC.</abstract><cop>Cairo, Egypt</cop><pub>Hindawi Publishing Corporation</pub><pmid>25177719</pmid><doi>10.1155/2014/312704</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record>
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subjects Adult
Aged
Carcinoma, Hepatocellular - genetics
Case-Control Studies
Colorectal cancer
Confidence intervals
Demographic aspects
Deoxyribonucleic acid
Development and progression
DNA
Female
Gene expression
Genetic aspects
Genetic engineering
Genetic variation
Genotype & phenotype
Health aspects
Hepatoma
Hospitals
Humans
Liver cancer
Liver Neoplasms - genetics
Male
Medical imaging
MicroRNA
MicroRNAs
MicroRNAs - genetics
Middle Aged
NMR
Nuclear magnetic resonance
Polymorphism, Single Nucleotide
Population
Risk reduction
Studies
title Association between a Variant in MicroRNA-646 and the Susceptibility to Hepatocellular Carcinoma in a Large-Scale Population
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