Fish Collagen Surgical Compress Repairing Characteristics on Wound Healing Process In Vivo

The development of biomaterials with the potential to accelerate wound healing is a great challenge in biomedicine. In this study, four types of samples including pepsin soluble collagen sponge (PCS), acid soluble collagen sponge (ACS), bovine collagen electrospun I (BCE I) and bovine collagen elect...

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Bibliographic Details
Published in:Marine drugs 2019-01, Vol.17 (1), p.33
Main Authors: Chen, Jingjing, Gao, Kaili, Liu, Shu, Wang, Shujun, Elango, Jeevithan, Bao, Bin, Dong, Jun, Liu, Ning, Wu, Wenhui
Format: Article
Language:English
Subjects:
Biocompatibility
Biological activity
Biomaterials
Biomedical materials
Cell division
Collagen
Contraction
Cytokines
Cytotoxicity
Dressing
Electrospinning
Epidermal growth factor
Extracellular matrix
Fibroblast growth factors
Fibroblasts
fibroblasts proliferation and differentiation
Fish
Freshwater fishes
Hydroxyproline
Inflammation
Pepsin
Proliferation
Proteins
Tilapia
Tissue engineering
Wound healing
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Summary:The development of biomaterials with the potential to accelerate wound healing is a great challenge in biomedicine. In this study, four types of samples including pepsin soluble collagen sponge (PCS), acid soluble collagen sponge (ACS), bovine collagen electrospun I (BCE I) and bovine collagen electrospun II (BCE II) were used as wound dressing materials. We showed that the PCS, ACS, BCE I and BCE II treated rats increased the percentage of wound contraction, reduced the inflammatory infiltration, and accelerated the epithelization and healing. PCS, ACS, BCE I, and BCE II significantly enhanced the total protein and hydroxyproline level in rats. ACS could induce more fibroblasts proliferation and differentiation than PCS, however, both PCS and ACS had a lower effect than BCE I and BCE II. PCS, ACS, BCE I, and BCE II could regulate deposition of collagen, which led to excellent alignment in the wound healing process. There were similar effects on inducing the level of cytokines including EGF, FGF, and vascular endothelial marker CD31 among these four groups. Accordingly, this study disclosed that collagens (PCS and ACS) from tilapia skin and bovine collagen electrospun (BCE I and BCE II) have significant bioactivity and could accelerate wound healing rapidly and effectively in rat model.
ISSN:1660-3397
1660-3397
DOI:10.3390/md17010033