Reprint of “Preclinical and clinical effects of Coleus forskohlii, Salacia reticulata and Sesamum indicum modifying pancreatic lipase inhibition in vitro and reducing total body fat”

•C. forskohlii, S. reticulata and S. indicum showed different inhibitory effect on activity of pancreatic lipase.•Three herb extracts treatment resulted in synergistic inhibited pancreatic lipase.•Supplemented C. forskohlii decreased appetite.•C. forskohlii significantly decreased caloric intake in...

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Bibliographic Details
Published in:Journal of functional foods 2015-10, Vol.18, p.994-1001
Main Authors: Badmaev, Vladimir, Hatakeyama, Yoshitaka, Yamazaki, Noriyuki, Noro, Akira, Mohamed, Faizal, Ho, Chi-Tang, Pan, Min-Hsiung
Format: Article
Language:English
Subjects:
Body fat
Coleus forskohlii
Pancreatic lipase
Salacia reticulate
Sesamum indicum
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Summary:•C. forskohlii, S. reticulata and S. indicum showed different inhibitory effect on activity of pancreatic lipase.•Three herb extracts treatment resulted in synergistic inhibited pancreatic lipase.•Supplemented C. forskohlii decreased appetite.•C. forskohlii significantly decreased caloric intake in the clinical study. The herbal compositions of Coleus forskohlii, Salacia reticulata, and Sesamum indicum, standardized for forskolin, mangiferin, and sesamin, respectively, were shown, in vitro, to inhibit pancreatic lipase with differing degrees and dynamics. In the placebo controlled six weeks clinical study the daily intake of 1000 mg C. forskohlii stand-alone standardized for 10% forskolin, showed statistically significant lowering of total body fat vs. baseline and placebo group (p 
ISSN:1756-4646
2214-9414
DOI:10.1016/j.jff.2015.05.027