Span of spleen is associated with disability status in multiple sclerosis: a cross-sectional abdominopelvic ultrasonography study

Characteristics of livers and spleens of people with multiple sclerosis (pwMS) could constitute good biomarkers of MS-related characteristics such as the disability status. To test the hypothesis “the gross anatomical features of livers and spleens, are not similar between pwMS with different diseas...

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Bibliographic Details
Published in:Scientific reports 2024-07, Vol.14 (1), p.15297-11, Article 15297
Main Authors: Etemadifar, Masoud, Alaei, Seyyed-Ali, Salari, Mehri, Sedaghat, Nahad
Format: Article
Language:English
Subjects:
692/308/53/2422
692/308/53/2423
692/53/2422
692/53/2423
692/617/375/1666
692/698/2741/288
692/699/375/1666
Adult
Autoimmune diseases
Cross-Sectional Studies
Fatty liver
Female
Humanities and Social Sciences
Humans
Iran
Liver - diagnostic imaging
Liver - pathology
Liver diseases
Male
Middle Aged
multidisciplinary
Multiple sclerosis
Multiple Sclerosis - diagnostic imaging
Non-alcoholic Fatty Liver Disease - diagnostic imaging
Rituximab
Science
Science (multidisciplinary)
Spleen
Spleen - diagnostic imaging
Ultrasonic imaging
Ultrasonography - methods
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Summary:Characteristics of livers and spleens of people with multiple sclerosis (pwMS) could constitute good biomarkers of MS-related characteristics such as the disability status. To test the hypothesis “the gross anatomical features of livers and spleens, are not similar between pwMS with different disease characteristics” a cross-sectional study was conducted on pwMS seen at the Isfahan MS clinic, Iran, from February until December 2023. Definitive, otherwise-healthy, pwMS were enrolled after an initial laboratory evaluation. Presence/absence and grading of non-alcoholic fatty liver disease (NAFLD) and the span of spleen were determined by a radiologist using high-resolution abdominopelvic ultrasonography. 193 pwMS (160 women) were enrolled. Of whom, 143 (74.1%) were receiving first-line disease-modifying therapies (DMTs), 24 (12.4%) fingolimod, and 26 (13.5%) rituximab. The span of spleen was negatively associated with EDSS (adjusted β [SE] − 4.08 [1.52], p   0.05). Receiver operating characteristic analysis showed, spleen span performs significant but poor in discrimination of EDSS > 1 from EDSS = 1 (area under curve [AUC] 0.62, SE 0.05, p  
ISSN:2045-2322
2045-2322
DOI:10.1038/s41598-024-66216-5