Mediation of 10-Year Cardiovascular Disease Risk between Inflammatory Diet and Handgrip Strength: Base on NHANES 2011-2014

• Published in: Nutrients 2023-02, Vol.15 (4), p.918
• Main Authors: Xie, Zechun, Wang, Ling, Sun, Mengzi, Wang, Rui, Li, Jing, Wang, Xuhan, Guo, Ruirui, Dong, Yibo, Wang, Yuxiang, Li, Bo
• Format: Article
• Language: English
• Subjects: Adult; Age; Blood pressure; Body mass index; Cardiovascular disease; Cardiovascular Diseases; Causes of; Chronic illnesses; Cigarette smoking; Complications and side effects; Cross-sectional studies; Demographic aspects; Diabetes; Diet; Drug addiction; Frailty; Gender; Grip strength; Hand Strength; handgrip strength; Health aspects; Health risks; Heart; Humans; Hypertension; Impairment; Inflammation; inflammatory diet; mediation; Mortality; Muscle strength; Muscle weakness; NHANES; Nutrients; Nutrition; Nutrition research; Nutrition Surveys; Older people; Public health; Risk; Risk Factors; Smoking; Womens health
• ISSN: 2072-6643; 2072-6643
• DOI: 10.3390/nu15040918

Dietary inflammatory index (DII) and handgrip strength (HGS) were correlated, and both were associated with cardiovascular disease (CVD). However, the role of the 10-year CVD risk in the relationship between DII and grip strength remains uncertain. This study involved 5691 adults from the National Health and Nutrition Examination Survey (NHANES) in 2011-2014. Dietary inflammation, 10-year CVD risk and relative grip strength were assessed by the Dietary Inflammation Index, the Framingham Risk Score (FRS) and handgrip strength adjusted BMI. Linear regression analyses and mediation analysis were used to explore these associations. Both DII and 10-year CVD risk were negatively associated with relative handgrip strength, and DII was positively associated with 10-year CVD risk. Additionally, 10-year CVD risk partially mediated the association between DII and relative handgrip strength by a 11.8% proportion. Specifically, the mediating effect of the 10-year risk of CVD varied by gender and age. Reducing the 10-year risk of CVD attenuates the effect of an inflammatory diet on relative grip strength impairment. Therefore, we recommend reducing the effect of inflammatory diet on grip strength impairment by controlling any of the FRS parameters, such as lowering blood pressure and smoking cessation, especially with targeted measures for different populations.