Associations between obesity, weight change and decreased renal function in Korean type 2 diabetic patients: a longitudinal follow-up study

• Published in: BMC endocrine disorders 2021-09, Vol.21 (1), p.188-188, Article 188
• Main Authors: Kim, Bo-Yeon, Choi, Dug-Hyun, Jung, Chan-Hee, Mok, Ji-Oh, Kim, Chul-Hee
• Format: Article
• Language: English
• Subjects: Analysis; Biomarkers - blood; Body mass index; Body Weight; Body weight changes; Body weight loss; Care and treatment; Cholesterol; Chronic illnesses; Creatinine; Decreased renal function; Diabetes; Diabetes mellitus; Diabetes mellitus (non-insulin dependent); Diabetes Mellitus, Type 2 - complications; Diabetic Nephropathies - epidemiology; Diabetic Nephropathies - etiology; Diabetic Nephropathies - pathology; Diabetics; Female; Follow-Up Studies; Glomerular Filtration Rate; Humans; Hypertension; Kidney - physiopathology; Kidney diseases; Laboratories; Longitudinal Studies; Male; Metabolism; Middle Aged; Multivariate analysis; Obesity; Obesity - physiopathology; Overweight; Patients; Population; Prognosis; Renal function; Republic of Korea - epidemiology; Surveys; Type 2; Type 2 diabetes; Urine; Weight control
• ISSN: 1472-6823; 1472-6823
• DOI: 10.1186/s12902-021-00853-z

We aimed to examine the associations between the risk of decreased renal function, obesity, and weight changes in Korean type 2 diabetic patients with normal renal function. Type 2 diabetic patients (n = 1060) who visited the diabetic clinic at Soonchunhyang University Bucheon Hospital between 2001 and 2007 with follow up surveys completed in 2016 to 2017 were recruited into the study. Decreased renal function was defined as an estimated glomerular filtration rate  10% was associated with the risk of decreased renal function after adjusting for clinical variables in type 2 diabetic patients with normal renal function at baseline (OR 1.43; CI 1.11-2.00; p = 0.016). Weight loss was not associated with the risk of decreased renal function in type 2 diabetic patients with normal renal function at baseline. Baseline obesity was associated with the increased risk of decreased renal function in Korean type 2 diabetic patients with normal renal function. Weight gain > 10% independently predicted the risk of decreased renal function. Large prospective studies are needed to clarify causal associations between obesity, weight change, and decreased renal function in patients with type 2 diabetes.