Multisite gynecologic endometrioid adenocarcinomas: Can mutation profiling be used to distinguish synchronous primary cancers from metastases?

•Mutation profiling may help determine clonality in multisite endometrioid carcinomas.•Molecular profiling will improve our understanding of multisite endometrioid carcinomas.•Multisite endometrioid carcinomas that arise as synchronous primary neoplasms may have an adverse prognosis. It is well reco...

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Bibliographic Details
Published in:Gynecologic oncology reports 2022-12, Vol.44, p.101076, Article 101076
Main Authors: Barnes, Dominique, Mohammad, Nissreen, Hoang, Lien, Anglesio, Michael, Hollis, Robert L., Gourley, Charlie, Stuart, Heather C., Carey, Mark S., Stuart, Gavin C.E.
Format: Article
Language:English
Subjects:
Case Reports and Case Series
Clonality
Endometrioid carcinoma
Gynecologic cancers
Mutation analysis
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Summary:•Mutation profiling may help determine clonality in multisite endometrioid carcinomas.•Molecular profiling will improve our understanding of multisite endometrioid carcinomas.•Multisite endometrioid carcinomas that arise as synchronous primary neoplasms may have an adverse prognosis. It is well recognized that some patients with endometrioid gynecological cancers have tumors arising in multiple sites (ovary, endometrium, and endometriosis) at the time of diagnosis. Molecular analysis has helped discern whether these multisite cancers represent synchronous primary tumors or alternatively metastatic disease. We present a complex case of a patient with endometrioid carcinomas arising in multiple sites. We discuss the use of mutation profiling to discern clonality and highlight how this information may inform the clinical management of such cases.
ISSN:2352-5789
2352-5789
DOI:10.1016/j.gore.2022.101076