Local adaptation and future climate vulnerability in a wild rodent

• Published in: Nature communications 2023-11, Vol.14 (1), p.7840-7840, Article 7840
• Main Authors: Marková, Silvia, Lanier, Hayley C., Escalante, Marco A., da Cruz, Marcos O. R., Horníková, Michaela, Konczal, Mateusz, Weider, Lawrence J., Searle, Jeremy B., Kotlík, Petr
• Format: Article
• Language: English
• Subjects: 45/22; 45/23; 631/158/2165; 631/181; 631/181/457; 631/208/182; Adaptation; Anthropogenic factors; Climate change; Gene sequencing; Genes; Genetic analysis; Genomes; Human influences; Humanities and Social Sciences; Hypoxia; multidisciplinary; Peripheral populations; Populations; Science; Science (multidisciplinary); Species extinction; Variation; Whole genome sequencing
• ISSN: 2041-1723; 2041-1723
• DOI: 10.1038/s41467-023-43383-z

As climate change continues, species pushed outside their physiological tolerance limits must adapt or face extinction. When change is rapid, adaptation will largely harness ancestral variation, making the availability and characteristics of that variation of critical importance. Here, we used whole-genome sequencing and genetic-environment association analyses to identify adaptive variation and its significance in the context of future climates in a small Palearctic mammal, the bank vole ( Clethrionomys glareolus ). We found that peripheral populations of bank vole in Britain are already at the extreme bounds of potential genetic adaptation and may require an influx of adaptive variation in order to respond. Analyses of adaptive loci suggest regional differences in climate variables select for variants that influence patterns of population adaptive resilience, including genes associated with antioxidant defense, and support a pattern of thermal/hypoxic cross-adaptation. Our findings indicate that understanding potential shifts in genomic composition in response to climate change may be key to predicting species’ fate under future climates. A species’ response to anthropogenic climate change may depend on its adaptations to past climate changes. Here, the authors use whole-genome resequencing and genetic-environment association to identify genes important for local adaptation and project adaptation under future climate scenarios across bank vole populations in Britain.