Comparative effects of methanol leaf extract of Moringa oleifera and ascorbic acid on haematological and histopathological changes induced by subchronic lead toxicity in male wistar rats

This work was aimed at comparing the effects of methanol leaf extract of Moringa oleifera (MLEMO) and ascorbic acid (AA) on haematological changes induced by subchronic lead (Pb) toxicity in male Wistar rats. Thirty-six adult male Wistar rats were randomly grouped into 6 rats per group. Group I rece...

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Published in:Pharmacological research. Modern Chinese medicine 2022-03, Vol.2, p.100031, Article 100031
Main Authors: Usman, Abubakar, Kawu, Mohammed Umaru, Shittu, Muftau, Saleh, Ahmadu, Jolayemi, Kelvin Olutimilehin, Ibrahim, Nuraddeen Bello, Oyetunde, Joshua Seyi, Okoronkwo, Magdalene Ogbonneya
Format: Article
Language:English
Subjects:
Ascorbic acid
Haematological
Lead
Moringa oleifera
Sub-chronic
Toxicity
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Summary:This work was aimed at comparing the effects of methanol leaf extract of Moringa oleifera (MLEMO) and ascorbic acid (AA) on haematological changes induced by subchronic lead (Pb) toxicity in male Wistar rats. Thirty-six adult male Wistar rats were randomly grouped into 6 rats per group. Group I received distilled water (2 mL/kg) whereas, groups II, III, IV, V and VI were administered Pb (190 mg/kg), Pb+AA (100 mg/kg), Pb+MLEMO (500 mg/kg), Pb+AA+MLEMO and Pb+AA (50 mg/kg) +MLEMO (250 mg/kg) respectively.  All agents were administered daily by oral gavage for 6 weeks. Blood samples were collected for haematological analysis. Inappetence, facial swelling, emaciation, back arching and nasal discharge were observed only in group II animals. There was significant (P
ISSN:2667-1425
2667-1425
DOI:10.1016/j.prmcm.2021.100031