Heat Stress Alters the Effect of Eimeria maxima Infection on Ileal Amino Acids Digestibility and Transporters Expression in Meat-Type Chickens

Eimeria (E.) maxima invades the midgut of chickens and destroys the intestinal mucosa, impacting nutrient digestibility and absorption. Heat stress (HS) commonly affects the broiler chicken and contributes to inflammation and oxidative stress. We examined the independent and combined effects of HS a...

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Bibliographic Details
Published in:Animals (Basel) 2022-06, Vol.12 (12), p.1554
Main Authors: Ghareeb, Ahmed F. A., Schneiders, Gustavo H., Foutz, James C., Milfort, Marie C., Fuller, Alberta L., Yuan, Jianmin, Rekaya, Romdhane, Aggrey, Samuel E.
Format: Article
Language:English
Subjects:
Absorption
Amino acids
amino acids’ transporters
apparent ileal digestibility
Birds
broilers
Chickens
Digestibility
E. maxima
Economic impact
Eimeria
Feeds
Gene expression
Generalized linear models
Heat
Heat stress
Heat tolerance
Ileum
Impact analysis
Infections
Intensive farming
Intestine
Meat
Midgut
Morbidity
mRNA expression
Nutrients
Oxidative stress
Physiology
Poultry
Small intestine
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Summary:Eimeria (E.) maxima invades the midgut of chickens and destroys the intestinal mucosa, impacting nutrient digestibility and absorption. Heat stress (HS) commonly affects the broiler chicken and contributes to inflammation and oxidative stress. We examined the independent and combined effects of HS and E. maxima infection on apparent amino acid ileal digestibility (AID) and mRNA expression of amino acid transporters in broiler chickens (Ross 708). There were four treatment groups: thermoneutral-control (TNc) and infected (TNi), heat-stress control (HSc) and infected (HSi), six replicates of 10 birds/treatment. Ileal content and tissue were sampled at 6 d post infection to determine AID and transporters expression. Surprisingly, the HSi chickens exposed to two critical stressors exhibited normal AID. Only the TNi group displayed reduction in AID. Using TNc as control, the HSc group showed upregulated CAT1, LAT4, TAT1, SNAT1, and SNAT7. The HSi group showed upregulated CAT1 and LAT1, and downregulated b0,+AT, rBAT, SNAT1, and SNAT2. The TNi group showed upregulated CAT1, LAT1, and SNAT1 and downregulated B0AT1, b0,+AT, rBAT, LAT4, and TAT1. The expression of all enterocytic-apical and about half of the basolateral transporters was higher in the HSi group than in the TNi group, indicating that HS can putatively alleviate the E. maxima adverse effect on ileal digestion and absorption.
ISSN:2076-2615
2076-2615
DOI:10.3390/ani12121554