Polyoxometalate-based heterojunction with NIR light-facilitated photocatalytic W6+/W5+ redox cycling for enhanced bacteria-infected wound healing

• Published in: Materials & design 2023-02, Vol.226, p.111673, Article 111673
• Main Authors: Lv, Mingzhu, Xu, Zhou, Yong, Yuan, Wang, Huan, Liu, Chenghui, Xu, Qiqi, Du, Guobo, Xie, Jiani, You, Yong, Xiao, Jiangwei, Jiang, Guohui
• Format: Article
• Language: English
• Subjects: Antibacterial and anti-biofilm therapy; Heterojunction structures; Near-infrared photocatalytic and photothermal therapy; Peroxidase-like catalytic activity; Polyoxometalates
• ISSN: 0264-1275; 1873-4197
• DOI: 10.1016/j.matdes.2023.111673

We reported a polyoxometalate-based heterojunction (GdP5W30@WS2) with shifting or mixed redox states (W6+/W5+) that can realize near-infrared (NIR) Light-facilitated photocatalytic W6+/W5+ redox cycling for enhanced POD-like catalytic activity and photothermal therapy of bacterial infections. [Display omitted] •GdP5W30@WS2, a polyoxometalate-based heterojunction nanocomposite with peroxidase (POD)-like catalytic activity, was introduced to treat bacteria-infected diseases.•Near-infrared (NIR) laser-enhanced POD-like catalytic activity of GdP5W30@WS2 was achieved via NIR-driven photocatalytic W6+/W5+ rapid redox cycling.•This nanocomposite also exhibited excellent photothermal effect and glutathione (GSH) exhaustion performance for more effective reactive oxygen species (ROS) production.•GdP5W30@WS2 realized chemodynamic/photothermal performance amplified with NIR-photocatalytic action for considerabled biofilm microenvironment (BME)-activated synergistic therapy. Metal-based nanomaterials with shifting or mixed redox states have been widely applied for combating against bacteria-infected diseases by virtue of their peroxidase (POD)-like catalytic activity. Herein, a polyoxometalate-based heterojunction (GdP5W30@WS2) with shifting or mixed redox states (W6+/W5+) is devised to achieve boosted reactive oxygen species (ROS) generation by near-infrared (NIR) laser-facilitated W6+/W5+ redox cycling for accelerated bacteria-infected wound healing. On the one hand, under the exposure to NIR laser, WS2 as electron donor could be stimulated to transfer electrons to GdP5W30, which promotes the reduction from W6+ to W5+ active sites on the surface of the GdP5W30. Consequently, the regenerated W5+ active sites could catalyze endogenous overexpressed H2O2 to persistently generate ROS, which displays enhanced POD-like catalytic activity for chemodynamic therapy (CDT) by NIR-driven photocatalytic W6+/W5+ redox cycling. Moreover, GdP5W30@WS2 also displays favorable glutathione (GSH)-activated photothermal performance by W6+-triggered GSH exhaustion for sufficient ROS generation, thereby facilitating the synergistic therapeutic efficiency of photothermal therapy (PTT) and CDT. We expect that the present work will promote the development of the heterojunction with shifting or mixed redox states for biofilm elimination based on NIR-facilitated enzyme-like catalytic activity, which may act as a candidate for BME-activated synergistic therapy.