Relationship between heart failure and intestinal inflammation in infants with congenital heart disease

The association between heart failure (HF) and intestinal inflammation caused by a disturbed intestinal microbiota in infants with congenital heart disease (CHD) was investigated. Twenty infants with HF and CHD who were admitted to our hospital between October 2021 and March 2022 were included in th...

Full description

Saved in:
Bibliographic Details
Published in:BMC microbiology 2024-03, Vol.24 (1), p.98-98, Article 98
Main Authors: Zhang, Qi-Liang, Chen, Xiu-Hua, Zhou, Si-Jia, Lei, Yu-Qing, Chen, Qiang, Cao, Hua
Format: Article
Language:English
Subjects:
Abundance
Bacteria
Cardiac function
Cardiovascular disease
Cardiovascular diseases
Care and treatment
Children
Complications and side effects
Congenital diseases
Congenital heart disease
Congestive heart failure
Correlation
Correlation analysis
Development and progression
Diseases
Enterococcus
Enterococcus - genetics
Enzymes
Feces
Genetic testing
Health aspects
Heart
Heart Defects, Congenital - complications
Heart diseases
Heart failure
Heart Failure - complications
Heart function
Hospitals
Host-bacteria relationships
Humans
IL-1β
Immunoassay
Immunoassays
Infant
Infants
Inflammation
Inflammatory response
Interleukin 10
Interleukin 4
Interleukin 6
Intestinal inflammation
Intestinal microbiota
Intestinal microflora
Intestine
Medical research
Medicine, Experimental
Microbiota
Microbiota (Symbiotic organisms)
Microorganisms
Normal distribution
Pathogenesis
Pathogenic bacteria
Pediatric cardiology
Pulmonary arteries
Reagents
Risk factors
Sample size
Statistical analysis
Tumor necrosis factor
Tumor Necrosis Factor-alpha
Tumor necrosis factor-α
Citations: Items that this one cites
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The association between heart failure (HF) and intestinal inflammation caused by a disturbed intestinal microbiota in infants with congenital heart disease (CHD) was investigated. Twenty infants with HF and CHD who were admitted to our hospital between October 2021 and March 2022 were included in this study. Twenty age- and sex-matched infants without HF at our hospital were selected as the control group. Faecal samples were obtained from each participant and analysed by enzyme-linked immunoassay and 16 S rDNA sequencing to assess intestinal inflammatory factors and the microbiota. The levels of intestinal inflammatory factors, including IL-1β, IL-4, IL-6, IL-17 A and TNF-α, were greatly increased, while the levels of IL-10 were significantly decreased in the HF group compared to the control group (p 
ISSN:1471-2180
1471-2180
DOI:10.1186/s12866-024-03229-0