Erythrocytosis caused by giant chromophobe renal cell carcinoma: a case report indicating a 9‐year misdiagnosis of polycythemia vera

Background Erythrocytosis, a rare paraneoplastic syndrome, generally occurs in patients with clear cell renal cell carcinoma and has never been reported in patients with chromophobe renal cell carcinoma. Case presentation We report a case of a young man suffering from a giant (22‐cm) mass on his lef...

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Bibliographic Details
Published in:Ai zheng 2017-09, Vol.36 (1), p.1-6, Article 72
Main Authors: Guo, Renbo, Liang, Yiran, Yan, Lei, Xu, Zhonghua, Ren, Juchao
Format: Article
Language:English
Subjects:
Abdomen
Adult
Biopsy
Blood cancer
Blood tests
Bone marrow
Carcinoma, Renal Cell - blood
Carcinoma, Renal Cell - pathology
Case Report
Case reports
Chromophobe renal cell carcinoma
Complications and side effects
Diagnosis
Diagnostic Errors
Erythrocytosis
Humans
Kidney cancer
Leukemia
Male
Misdiagnosis
Mutation
Pain
Patients
Phlebotomy
Polycythemia
Polycythemia - etiology
Polycythemia - pathology
Polycythemia vera
Renal cell carcinoma
Risk factors
Surgery
Tomography
Veins & arteries
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Summary:Background Erythrocytosis, a rare paraneoplastic syndrome, generally occurs in patients with clear cell renal cell carcinoma and has never been reported in patients with chromophobe renal cell carcinoma. Case presentation We report a case of a young man suffering from a giant (22‐cm) mass on his left kidney. Because of a history of polycythemia vera, the patient had been treated for the condition for 9 years. Radical nephrectomy was successfully performed, and the postoperative pathologic examination confirmed a diagnosis of chromophobe renal cell carcinoma. Unexpectedly, the symptom of erythrocytosis disappeared after the surgery. Further examination and analysis were performed, and we finally attributed his erythrocytosis to chromophobe renal cell carcinoma. Conclusions Chromophobe renal cell carcinoma could cause erythrocytosis, but the clear‐cut mechanism needs further research. Secondary erythrocytosis such as those related with renal tumors should be taken into consideration during the diagnosis of polycythemia vera.
ISSN:2523-3548
1944-446X
1000-467X
2523-3548
1944-446X
DOI:10.1186/s40880-017-0238-z