Lethal BCG-osis, in the context of superficial urothelial bladder carcinoma, diagnosed in autopsy

Intra-vesicular Bacillus Calmette–Guérin (BCG) immuno-therapy is a cornerstone in the treatment of superficial bladder carcinoma. However, it can rarely cause BCG-osis, a systemic infection, potentially fatal. A case of a 73year old man, diagnosed with superficial urothelial bladder carcinoma five m...

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Bibliographic Details
Published in:Egyptian journal of forensic sciences 2016-09, Vol.6 (3), p.284-288
Main Authors: Madentzoglou, Maria S., Nathena, Despoina, Sinatkas, Vaios, Michalodimitrakis, Manolis, Kranioti, Elena F.
Format: Article
Language:English
Subjects:
Autopsy
BCG-osis
Superficial urothelial bladder carcinoma
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Summary:Intra-vesicular Bacillus Calmette–Guérin (BCG) immuno-therapy is a cornerstone in the treatment of superficial bladder carcinoma. However, it can rarely cause BCG-osis, a systemic infection, potentially fatal. A case of a 73year old man, diagnosed with superficial urothelial bladder carcinoma five months ago, who died with clinical features of septic shock one day after BCG therapeutic maintenance infusion, is presented. The cause of death, BCG-osis, was revealed during autopsy.
ISSN:2090-536X
2090-5939
DOI:10.1016/j.ejfs.2015.07.007