Protective Role of Picralima nitida Seed Extract in High-Fat High-Fructose-Fed Rats

Picralima nitida is a therapeutic herb used in ethnomedicine for the management of several disease conditions including diabetes. This study examined the potential palliative effect of aqueous seed extract of Picralima nitida (APN) on dyslipidemia, hyperglycemia, oxidative stress, insulin resistance...

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Bibliographic Details
Published in:Advances in pharmacological and pharmaceutical sciences 2020-10, Vol.2020 (2020), p.1-11
Main Authors: Rotimi, Solomon Oladapo, Iheagwam, Franklyn Nonso, Bisi-Adeniyi, Titilayo Ifeoluwa, Osaigbovo, Daniel Ikpomwosa, De Campos, Opeyemi Christianah, Chinedu, Shalom Nwodo
Format: Article
Language:English
Subjects:
Acids
Blood cholesterol
Body weight
Calories
Cholesterol
Creatinine
Diabetes
Diabetes therapy
Diet
Drinking water
Drug dosages
Enzymes
Ethylenediaminetetraacetic acid
Fructose
Glucose
Health aspects
Hyperglycemia
Insulin resistance
Isoenzymes
Laboratory animals
Leptin
Low density lipoproteins
Medical research
Medicine, Experimental
Metabolic disorders
Metabolic syndrome
Oxidative stress
Pharmaceutical sciences
Pharmacology
Plasma
Registered nurses
Rodents
Seeds
Type 2 diabetes
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Summary:Picralima nitida is a therapeutic herb used in ethnomedicine for the management of several disease conditions including diabetes. This study examined the potential palliative effect of aqueous seed extract of Picralima nitida (APN) on dyslipidemia, hyperglycemia, oxidative stress, insulin resistance, and the expression of some metabolic genes in high-fat high-fructose-fed rats. Experimental rats (2 months old) were fed a control diet or a high-fat diet with 25% fructose (HFHF diet) in their drinking water for nine weeks. APN was administered orally during the last four weeks. Anthropometric and antioxidant parameters, lipid profile, plasma glucose, and insulin levels and the relative expression of some metabolic genes were assessed. APN caused a significant decrease (P
ISSN:2633-4682
2633-4690
2633-4690
DOI:10.1155/2020/5206204