High HDL-C and high LDL-C are risk factors of pterygium in a population-based cross-sectional study in Southern China: the Dongguan Eye Study

ObjectivesTo investigate the relationship between serum lipids and pterygium in a large-scale rural population aged 40 years or older from Southern China.Study designThe Dongguan Eye Study was a cross-sectional population-based study from September 2011 to February 2012.SettingThe area was set in th...

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Published in:BMJ open 2022-06, Vol.12 (6), p.e058649
Main Authors: Zang, Siwen, Chen, Yanlei, Guo, Haike, Zhang, Min, Zhang, Guanrong, Zhang, Lixin, Zhang, Liang, Liu, Qingyang, Zeng, Jin, Lo, Chun-Han, Cui, Ying, Meng, Qianli
Format: Article
Language:English
Subjects:
Adult
Body mass index
China - epidemiology
Cholesterol
Cholesterol, HDL
Cholesterol, LDL
Cross-Sectional Studies
High density lipoprotein
high-density lipoprotein-cholesterol
Humans
Low density lipoprotein
low-density lipoprotein-cholesterol
Ophthalmology
Population
Population-based studies
population-based study
Pterygium
risk factor
Risk Factors
Rural areas
Triglycerides
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Summary:ObjectivesTo investigate the relationship between serum lipids and pterygium in a large-scale rural population aged 40 years or older from Southern China.Study designThe Dongguan Eye Study was a cross-sectional population-based study from September 2011 to February 2012.SettingThe area was set in the rural area of Dongguan, Southern China.ParticipantsAdult rural population aged 40 or older.MethodsParticipants underwent physical, haematological and ophthalmic examinations.Primary and secondary outcome measuresThe frequency and risk factors of pterygium.ResultsA total of 11 357 participants were eligible for inclusion and 8952 (78.8%) participants were enrolled for the systemic and ophthalmic examinations. The prevalence of pterygium was 17.3% after adjusting the sex and age distribution, 22.0% in participants with hypercholesterolaemia (total cholesterol ≥6.22 mmol/L (240 mg/dL)) and 21.8% in those with low-density lipoprotein-cholesterol (LDL-C) ≥4.14 mmol/L (160 mg/dL), respectively. After adjusting for multiple confounding factors, higher level of high-density lipoprotein-cholesterol (HDL-C) (OR: 1.23, 95% CI: 1.06 to 1.41) and LDL-C (OR: 1.13, 95% CI: 1.06 to 1.20) were positively associated with the risk of pterygium. The ORs for HDL-C or LDL-C with pterygium were significantly greater in participants aged 40–49 years than those aged 50 years or above (P for interaction
ISSN:2044-6055
2044-6055
DOI:10.1136/bmjopen-2021-058649