Resting heart rate and antisocial behaviour: a Mendelian randomisation study

Observational studies frequently report phenotypic associations between low resting heart rate (RHR) and higher levels of antisocial behaviour (ASB), although it remains unclear whether this relationship reflects causality. To triangulate evidence, we conducted two-sample univariable Mendelian rando...

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Bibliographic Details
Published in:Scientific reports 2023-06, Vol.13 (1), p.10212-10212, Article 10212
Main Authors: Karwatowska, Lucy, Frach, Leonard, Schoeler, Tabea, Tielbeek, Jorim J., Murray, Joseph, de Geus, Eco, Viding, Essi, Pingault, Jean-Baptiste
Format: Article
Language:English
Subjects:
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Antisocial Personality Disorder
Autonomic nervous system
Genetic analysis
Genome-wide association studies
Genome-Wide Association Study
Genomes
Heart rate
Heart Rate - genetics
Heterogeneity
Humanities and Social Sciences
Humans
Linkage disequilibrium
Mendelian Randomization Analysis
multidisciplinary
Observational studies
Polymorphism, Single Nucleotide
Regression Analysis
Science
Science (multidisciplinary)
Sensitivity analysis
Single-nucleotide polymorphism
Social behavior
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Summary:Observational studies frequently report phenotypic associations between low resting heart rate (RHR) and higher levels of antisocial behaviour (ASB), although it remains unclear whether this relationship reflects causality. To triangulate evidence, we conducted two-sample univariable Mendelian randomisation (MR), multivariable MR and linkage disequilibrium score regression (LDSC) analyses. Genetic data were accessed from published genome-wide association studies (GWAS) for RHR (n = 458,835) and ASB (n = 85,359) for the univariable analyses, along with a third GWAS for heart rate variability (HRV; n = 53,174) for all other analyses. Genome-wide significant ( p  
ISSN:2045-2322
2045-2322
DOI:10.1038/s41598-023-37123-y