Facile synthesis of 4H-chromene derivatives via base-mediated annulation of ortho-hydroxychalcones and 2-bromoallyl sulfones

The cesium carbonate-mediated reaction of 2-bromoallyl sulfones and ortho-hydroxychalcones furnished 3-arylsulfonyl-4H-chromene derivatives in 58-67% yield (18 examples). 2-Bromoallyl sulfones functioned as synthetic surrogates for allenyl sulfones in the reaction.

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Bibliographic Details
Published in:Beilstein journal of organic chemistry 2016, Vol.12 (1), p.16-21
Main Authors: Thadkapally, Srinivas, Kunjachan, Athira C, Menon, Rajeev S
Format: Article
Language:English
Subjects:
allenes
Chemistry
chromenes
cyclocondenzation
Letter
sulfones
vinylic substitution
Online Access:Get full text
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Description
Summary:The cesium carbonate-mediated reaction of 2-bromoallyl sulfones and ortho-hydroxychalcones furnished 3-arylsulfonyl-4H-chromene derivatives in 58-67% yield (18 examples). 2-Bromoallyl sulfones functioned as synthetic surrogates for allenyl sulfones in the reaction.
ISSN:1860-5397
2195-951X
1860-5397
DOI:10.3762/bjoc.12.3