Acute Kidney Injury and Pediatric Bone Health

Acute kidney injury (AKI) has been associated with deleterious impacts on a variety of body systems. While AKI is often accompanied by dysregulation of mineral metabolism-including alterations in calcium, phosphate, vitamin D, parathyroid hormone, fibroblast growth factor 23, and klotho-its direct e...

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Bibliographic Details
Published in:Frontiers in pediatrics 2021-02, Vol.8, p.635628-635628
Main Authors: Hegde, Anisha, Denburg, Michelle R, Glenn, Dorey A
Format: Article
Language:English
Subjects:
AKI
fibroblast growth factor 23
klotho
parathyroid hormone
Pediatrics
skeleton
vitamin D
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Summary:Acute kidney injury (AKI) has been associated with deleterious impacts on a variety of body systems. While AKI is often accompanied by dysregulation of mineral metabolism-including alterations in calcium, phosphate, vitamin D, parathyroid hormone, fibroblast growth factor 23, and klotho-its direct effects on the skeletal system of children and adolescents remain largely unexplored. In this review, the pathophysiology of dysregulated mineral metabolism in AKI and its potential effects on skeletal health are discussed, including data associating AKI with fracture risk.
ISSN:2296-2360
2296-2360
DOI:10.3389/fped.2020.635628