Plasma metabolites are altered before and after diagnosis of preeclampsia or fetal growth restriction

Metabolomics is the study of small molecules (metabolites), within cells, tissues and biofluids. Maternal metabolites can provide important insight into the health and development of both mother and fetus throughout pregnancy. This study assessed metabolic profiles in the maternal circulation prior...

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Bibliographic Details
Published in:Scientific reports 2024-07, Vol.14 (1), p.15829-11, Article 15829
Main Authors: Bartho, Lucy A., McKeating, Daniel R., Walker, Susan P., Nijagal, Brunda, MacDonald, Teresa M., Pritchard, Natasha, Hannan, Natalie J., Perkins, Anthony V., Tong, Stephen, Kaitu’u-Lino, Tu’uhevaha J.
Format: Article
Language:English
Subjects:
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692/308/575
Acetyl-L-carnitine
Acids
Adult
Age
Biomarkers - blood
Biosynthesis
Birth weight
Case-Control Studies
Citric acid
Creatine
Diagnosis
Female
Fetal Growth Retardation - blood
Fetal Growth Retardation - diagnosis
Fetuses
Gestation
Humanities and Social Sciences
Humans
Infants
Metabolism
Metabolites
Metabolome
Metabolomics
Metabolomics - methods
multidisciplinary
Pre-eclampsia
Pre-Eclampsia - blood
Pre-Eclampsia - diagnosis
Preeclampsia
Pregnancy
Pregnancy complications
Prospective Studies
Science
Science (multidisciplinary)
tRNA
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Summary:Metabolomics is the study of small molecules (metabolites), within cells, tissues and biofluids. Maternal metabolites can provide important insight into the health and development of both mother and fetus throughout pregnancy. This study assessed metabolic profiles in the maternal circulation prior to and at the time of diagnosis of preeclampsia and fetal growth restriction. Maternal plasma samples were collected from two independent cohorts: (1) Established disease cohort: 50 participants diagnosed with early-onset preeclampsia (
ISSN:2045-2322
2045-2322
DOI:10.1038/s41598-024-65947-9