Biodiversity and Classification of Phages Infecting Lactobacillus brevis

Lactobacillus brevis is a lactic acid bacterium that is known as a food and beverage spoilage organism, and more specifically as a beer-spoiler. Phages of L. brevis have been described, but very limited data is available regarding temperate phages of L. brevis . Temperate phages may exert benefits t...

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Bibliographic Details
Published in:Frontiers in microbiology 2019-10, Vol.10, p.2396-2396
Main Authors: Feyereisen, Marine, Mahony, Jennifer, Neve, Horst, Franz, Charles M. A. P., Noben, Jean-Paul, O’Sullivan, Tadhg, Boer, Viktor, van Sinderen, Douwe
Format: Article
Language:English
Subjects:
bacteriophage
beer spoilage
genomic analysis
lactic acid bacteria
lysogeny
Microbiology
prophage
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Summary:Lactobacillus brevis is a lactic acid bacterium that is known as a food and beverage spoilage organism, and more specifically as a beer-spoiler. Phages of L. brevis have been described, but very limited data is available regarding temperate phages of L. brevis . Temperate phages may exert benefits to the host, while they may also be employed to combat beer spoilage. The current study reports on the incidence of prophage sequences present in nineteen distinct L. brevis genomes. Prophage induction was evaluated using mitomycin C exposure followed by genome targeted-PCR, electron microscopy and structural proteome analysis. The morphological and genome sequence analyses revealed significant diversity among L. brevis prophages, which appear to be dominated by members of the Myoviridae phage family. Based on this analysis, we propose a classification of L. brevis phages into five groups.
ISSN:1664-302X
1664-302X
DOI:10.3389/fmicb.2019.02396