Identifying the Target Traumatic Brain Injury Population for Hyperbaric Oxygen Therapy

Traumatic brain injury (TBI) results from direct penetrating and indirect non-penetrating forces that alters brain functions, affecting millions of individuals annually. Primary injury following TBI is exacerbated by secondary brain injury; foremost is the deleterious inflammatory response. One ther...

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Bibliographic Details
Published in:International journal of molecular sciences 2023-10, Vol.24 (19), p.14612
Main Authors: Schimmel, Samantha, El Sayed, Bassel, Lockard, Gavin, Gordon, Jonah, Young, Isabella, D’Egidio, Francesco, Lee, Jea Young, Rodriguez, Thomas, Borlongan, Cesar V
Format: Article
Language:English
Subjects:
Apoptosis
Brain
Brain research
Cell death
chronic impairments
Chronic traumatic encephalopathy
Concussion
Edema
Homeostasis
hyperbaric oxygen therapy
Hypoxia
Inflammation
Injuries
Intracranial pressure
Medical research
Medicine, Experimental
Metabolism
Mortality
Neurodegeneration
Oxygen therapy
Pathophysiology
Patients
Review
Traumatic brain injury
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Summary:Traumatic brain injury (TBI) results from direct penetrating and indirect non-penetrating forces that alters brain functions, affecting millions of individuals annually. Primary injury following TBI is exacerbated by secondary brain injury; foremost is the deleterious inflammatory response. One therapeutic intervention being increasingly explored for TBI is hyperbaric oxygen therapy (HBOT), which is already approved clinically for treating open wounds. HBOT consists of 100% oxygen administration, usually between 1.5 and 3 atm and has been found to increase brain oxygenation levels after hypoxia in addition to decreasing levels of inflammation, apoptosis, intracranial pressure, and edema, reducing subsequent secondary injury. The following review examines recent preclinical and clinical studies on HBOT in the context of TBI with a focus on contributing mechanisms and clinical potential. Several preclinical studies have identified pathways, such as TLR4/NF-kB, that are affected by HBOT and contribute to its therapeutic effect. Thus far, the mechanisms mediating HBOT treatment have yet to be fully elucidated and are of interest to researchers. Nonetheless, multiple clinical studies presented in this review have examined the safety of HBOT and demonstrated the improved neurological function of TBI patients after HBOT, deeming it a promising avenue for treatment.
ISSN:1422-0067
1661-6596
1422-0067
DOI:10.3390/ijms241914612