Effects of Pubertal Status and Inflammation on the Use of Ferritin to Define Iron Deficiency in Children With Overweight or Obesity

Background and aims: A worldwide increase in childhood overweight (OW) and obesity (OB) has been reported. OB is an inflammatory state which affects iron metabolism and the sensibility of the tests to detect iron deficiency (ID). Our aim was to evaluate the adequacy of current ferritin cut-offs to d...

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Published in:Nutrition and metabolic insights 2019, Vol.12, p.1178638819839064-1178638819839064
Main Authors: Muzzio, Maria Luz, Lozano Chiappe, Ezequiel S, Kabakian, Laura, Ferraro, Florencia, Landó, Ines, Alonso, Elizabeth, Fernández, Jorgelina, Peredo, Soledad, Brovarone, Lucrecia, Pia Santucci, Maria, Meroño, Tomás
Format: Article
Language:English
Subjects:
Anemia
Blood
Body mass index
Diabetes
Hemoglobin
Hypothyroidism
Inflammation
Iron
Metabolism
Obesity
Original Research
Overweight
Pediatrics
Population
Trends
Tumor necrosis factor-TNF
Variance analysis
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Summary:Background and aims: A worldwide increase in childhood overweight (OW) and obesity (OB) has been reported. OB is an inflammatory state which affects iron metabolism and the sensibility of the tests to detect iron deficiency (ID). Our aim was to evaluate the adequacy of current ferritin cut-offs to define ID in children with OW/OB. Methods: This cross-sectional study included 152 children (54% girls) aged (median [Q1-Q3]) 11 (8-13) years with OW/OB. Complete blood count and iron metabolism were evaluated. Low ferritin, transferrin saturation (TSat), and anemia were defined by age- and sex-specific cut-offs recommended by National Guidelines. Iron intake was assessed in a subgroup (n = 80) by a 24-hour dietary recall. Analyses were made according to pubertal development and ferritin tertiles. Results: The overall prevalence of low ferritin, TSat, and anemia was 2.6%, 23.8%, and 5.2%, respectively. Among pre-pubertal children (n = 87), the frequency of low TSat rose across ferritin tertiles (P 
ISSN:1178-6388
1178-6388
DOI:10.1177/1178638819839064