Effectiveness and Safety of Different Rivaroxaban Dosage Regimens in Patients with Non-Valvular Atrial Fibrillation: A Nationwide, Population-Based Cohort Study

The objective of this study is to evaluate the effectiveness of different rivaroxaban dosage regimens in preventing ischemic stroke and systemic thromboembolism among Asians. A retrospective cohort study was conducted on data from nationwide insurance claims in Taiwan. Patients with non-valvular atr...

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Bibliographic Details
Published in:Scientific reports 2018-02, Vol.8 (1), p.3451-9, Article 3451
Main Authors: Huang, Hsin-Yi, Lin, Shin-Yi, Cheng, Shou-Hsia, Wang, Chi-Chuan
Format: Article
Language:English
Subjects:
692/308/409
692/699/75/29/1309
Cohort analysis
Fibrillation
Health risk assessment
Hemorrhage
Humanities and Social Sciences
Ischemia
multidisciplinary
Population studies
Population-based studies
Science
Science (multidisciplinary)
Stroke
Thromboembolism
Warfarin
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Summary:The objective of this study is to evaluate the effectiveness of different rivaroxaban dosage regimens in preventing ischemic stroke and systemic thromboembolism among Asians. A retrospective cohort study was conducted on data from nationwide insurance claims in Taiwan. Patients with non-valvular atrial fibrillation under warfarin or rivaroxaban therapy were included. Propensity score matching was used to balance the covariates, and Cox-proportional hazard models were applied to compare the effectiveness and safety of each treatment group. Rivaroxaban was associated with a significantly lower risk of venous thromboembolism (hazard ratio [HR]: 0.51; 95% confidence interval [CI]: 0.29–0.92, P = 0.02) and intracranial hemorrhage (HR: 0.48; 95% CI: 0.32–0.72, P 
ISSN:2045-2322
2045-2322
DOI:10.1038/s41598-018-21884-y