Urate crystal deposition is associated with inflammatory markers and carotid artery pathology in patients with intercritical gout: results from the NOR-Gout study

BackgroundGout is of unknown reason associated with cardiovascular disease. Ultrasound is sensitive for detecting crystal deposition and plasma calprotectin is a sensitive inflammatory marker. This study explores the associations between crystal deposition, inflammation and carotid artery pathology....

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Published in:Rheumatic & musculoskeletal diseases open 2022-07, Vol.8 (2), p.e002348
Main Authors: Hammer, Hilde Berner, Rollefstad, Silvia, Semb, Anne Grete, Jensen, Gro, Karoliussen, Lars Fridtjof, Terslev, L, Haavardsholm, Espen A, Kvien, Tore K, Uhlig, Till
Format: Article
Language:English
Subjects:
Aggregates
Biomarkers
Body mass index
Cardiovascular disease
Cardiovascular Diseases
Carotid arteries
Creatinine
Crystal Arthropathies
Gout
Granulocytes
Inflammation
Laboratories
Mortality
Pathology
Proteins
Regression analysis
Rheumatism
Ultrasonic imaging
Ultrasonography
Veins & arteries
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Summary:BackgroundGout is of unknown reason associated with cardiovascular disease. Ultrasound is sensitive for detecting crystal deposition and plasma calprotectin is a sensitive inflammatory marker. This study explores the associations between crystal deposition, inflammation and carotid artery pathology.MethodA cross-sectional analysis of baseline assessments from the NOR-Gout study was undertaken. Crystal deposition was assessed by ultrasound (double contour, tophi, aggregates) and dual-energy CT (DECT) and laboratory assessments included plasma calprotectin. The carotid arteries were bilaterally examined for carotid intima–media thickness (cIMT) and presence of plaques. Spearman correlations, Mann-Whitney tests and linear regression analyses were used to explore associations between crystal deposition, inflammatory markers,and carotid pathology.Results202 patients with intercritical gout (95.5% men, mean (SD) age 56.5 (13.8) years, disease duration 7.9 (7.7) years) were included. Calprotectin was correlated with all scores of crystal deposition by ultrasound (r=0.26–0.32, p
ISSN:2056-5933
2056-5933
DOI:10.1136/rmdopen-2022-002348