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Examining the Effect of Chamomile on Clinical Symptoms and Hormonal Parameters Among Patients With Polycystic Ovarian Syndrome
Polycystic ovarian syndrome is the most common cause of infertility and endocrine disorder among women due to anovulation. The aim of the present study is to investigate the effect of chamomile on oligomenorrhea and hirsutism symptoms as well as hormonal parameters among patients suffering from poly...
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Published in: | Journal of family & reproductive health 2022-12, Vol.16 (4), p.248-253 |
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description | Polycystic ovarian syndrome is the most common cause of infertility and endocrine disorder among women due to anovulation. The aim of the present study is to investigate the effect of chamomile on oligomenorrhea and hirsutism symptoms as well as hormonal parameters among patients suffering from polycystic ovarian syndrome.
The present study is a randomized clinical trial performed on 70 patients with diagnosis of polycystic ovarian syndrome according to Rotterdam criteria referring to the infertility clinic of a university hospital. The patients were randomly assigned into intervention and control groups, with the former receiving two chamomile capsules 500 mg for three months, and the latter receiving two placebo capsules for 3 months. Both groups were evaluated in terms of laboratory parameters (FBS, LDL, and testosterone) on the third day of first and third cycles. The collected data were analyzed by SPSS 20.
The mean age, body mass index, marital status, history of infertility, and pregnancy rate showed no significant difference between the two groups. In the chamomile group, clinical symptoms of hirsutism (p |
doi_str_mv | 10.18502/jfrh.v16i4.11355 |
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The present study is a randomized clinical trial performed on 70 patients with diagnosis of polycystic ovarian syndrome according to Rotterdam criteria referring to the infertility clinic of a university hospital. The patients were randomly assigned into intervention and control groups, with the former receiving two chamomile capsules 500 mg for three months, and the latter receiving two placebo capsules for 3 months. Both groups were evaluated in terms of laboratory parameters (FBS, LDL, and testosterone) on the third day of first and third cycles. The collected data were analyzed by SPSS 20.
The mean age, body mass index, marital status, history of infertility, and pregnancy rate showed no significant difference between the two groups. In the chamomile group, clinical symptoms of hirsutism (p<0.001) and oligomenorrhea (p=0.048) decreased following the treatment, but significant difference was found between the two groups only in hirsutism symptoms (p=0.028). Regarding the parameters of FBS (p=0.06), HDL (p=0.224), cholesterol (p=0.99), triglyceride (p=0.106), testosterone (p=0.894), and LDL (p=0.61), no significant difference was observed between the two groups. Nevertheless, following the treatment, testosterone decreased in both placebo (p=0.005) and chamomile (p=0.001) groups.
overall, the chamomile therapeutic regimen has relatively been able to mitigate the clinical symptoms and testosterone levels in patients suffering from polycystic ovarian syndrome. Use of chamomile plant as a simple, inexpensive, and effective measure can be suggested for improving and treating patients with PCOS after confirmation by further studies.</description><identifier>ISSN: 1735-8949</identifier><identifier>EISSN: 1735-9392</identifier><identifier>DOI: 10.18502/jfrh.v16i4.11355</identifier><identifier>PMID: 37465426</identifier><language>eng</language><publisher>Iran: Tehran University of Medical Sciences</publisher><subject>Chamomile ; Clinical Symptom ; Hormonal Parameters ; Infertility ; Original ; Ovaries ; Polycystic Ovarian Syndrome ; Polycystic ovary syndrome ; Testosterone</subject><ispartof>Journal of family & reproductive health, 2022-12, Vol.16 (4), p.248-253</ispartof><rights>Copyright © 2022 Tehran University of Medical Sciences. Published by Tehran University of Medical Sciences.</rights><rights>2022. This work is published under https://creativecommons.org/licenses/by-nc/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>Copyright © 2022 Tehran University of Medical Sciences. Published by Tehran University of Medical Sciences. 2022</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.proquest.com/docview/2756692129/fulltextPDF?pq-origsite=primo$$EPDF$$P50$$Gproquest$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.proquest.com/docview/2756692129?pq-origsite=primo$$EHTML$$P50$$Gproquest$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,25753,27924,27925,37012,37013,44590,53791,53793,75126</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/37465426$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Afiat, Malihe</creatorcontrib><creatorcontrib>Akbari Lor, Azam</creatorcontrib><creatorcontrib>Najaf Najafi, Mona</creatorcontrib><creatorcontrib>Ghazanfarpour, Masumeh</creatorcontrib><creatorcontrib>Jafarabadi, Mina</creatorcontrib><title>Examining the Effect of Chamomile on Clinical Symptoms and Hormonal Parameters Among Patients With Polycystic Ovarian Syndrome</title><title>Journal of family & reproductive health</title><addtitle>J Family Reprod Health</addtitle><description>Polycystic ovarian syndrome is the most common cause of infertility and endocrine disorder among women due to anovulation. The aim of the present study is to investigate the effect of chamomile on oligomenorrhea and hirsutism symptoms as well as hormonal parameters among patients suffering from polycystic ovarian syndrome.
The present study is a randomized clinical trial performed on 70 patients with diagnosis of polycystic ovarian syndrome according to Rotterdam criteria referring to the infertility clinic of a university hospital. The patients were randomly assigned into intervention and control groups, with the former receiving two chamomile capsules 500 mg for three months, and the latter receiving two placebo capsules for 3 months. Both groups were evaluated in terms of laboratory parameters (FBS, LDL, and testosterone) on the third day of first and third cycles. The collected data were analyzed by SPSS 20.
The mean age, body mass index, marital status, history of infertility, and pregnancy rate showed no significant difference between the two groups. In the chamomile group, clinical symptoms of hirsutism (p<0.001) and oligomenorrhea (p=0.048) decreased following the treatment, but significant difference was found between the two groups only in hirsutism symptoms (p=0.028). Regarding the parameters of FBS (p=0.06), HDL (p=0.224), cholesterol (p=0.99), triglyceride (p=0.106), testosterone (p=0.894), and LDL (p=0.61), no significant difference was observed between the two groups. Nevertheless, following the treatment, testosterone decreased in both placebo (p=0.005) and chamomile (p=0.001) groups.
overall, the chamomile therapeutic regimen has relatively been able to mitigate the clinical symptoms and testosterone levels in patients suffering from polycystic ovarian syndrome. Use of chamomile plant as a simple, inexpensive, and effective measure can be suggested for improving and treating patients with PCOS after confirmation by further studies.</description><subject>Chamomile</subject><subject>Clinical Symptom</subject><subject>Hormonal Parameters</subject><subject>Infertility</subject><subject>Original</subject><subject>Ovaries</subject><subject>Polycystic Ovarian Syndrome</subject><subject>Polycystic ovary syndrome</subject><subject>Testosterone</subject><issn>1735-8949</issn><issn>1735-9392</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>PIMPY</sourceid><sourceid>DOA</sourceid><recordid>eNpdks1qGzEUhYfS0oQ0D9BNEXTTjV39j7QqwbhJIJBAW7oUkkbyyIxGrjQ29abPXsV2QlNtJI7O_bj3cprmPYJzJBjEn9c-9_Md4oHOESKMvWrOUUvYTBKJX5_eQlJ51lyWsob1ECw4ZW-bM9JSzijm582f5W8dwxjGFZh6B5beOzuB5MGi1zHFMDiQRrAYqsXqAXzbx82UYgF67MBNyjGNVX3QWUc3uVzAVVVWVZiCG6cCfoapBw9p2Nt9mYIF9zudgx4rZ-xyiu5d88brobjL033R_Pi6_L64md3dX98uru5mFkvEZgTSFmPkKJamw523miBjtbGISycMw5wbI6ETUhjbSeeN8Ix6Q7kQlkpNLprbI7dLeq02OUSd9yrpoA5Cyiulc21wcMoTjZGVhtYlU-yQRNJ4CSGH1HHYicr6cmRttia6ztZBsx5eQF_-jKFXq7RTCBIGGWWV8OlEyOnX1pVJxVCsGwY9urQtCgsiWwqxlNX68T_rOm1zXXp1tYxziRF-dKGjy-ZUSnb-uRsE1SEt6jEt6pAWdUhLrfnw7xjPFU_ZIH8B4GO9yw</recordid><startdate>20221201</startdate><enddate>20221201</enddate><creator>Afiat, Malihe</creator><creator>Akbari Lor, Azam</creator><creator>Najaf Najafi, Mona</creator><creator>Ghazanfarpour, Masumeh</creator><creator>Jafarabadi, Mina</creator><general>Tehran University of Medical Sciences</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>CWDGH</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9-</scope><scope>K9.</scope><scope>M0R</scope><scope>M0S</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope></search><sort><creationdate>20221201</creationdate><title>Examining the Effect of Chamomile on Clinical Symptoms and Hormonal Parameters Among Patients With Polycystic Ovarian Syndrome</title><author>Afiat, Malihe ; Akbari Lor, Azam ; Najaf Najafi, Mona ; Ghazanfarpour, Masumeh ; Jafarabadi, Mina</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c2915-3047221e429bd2dfca31bcabc169e8b5266bb90e898bcd9efb8f54fb4688c49a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Chamomile</topic><topic>Clinical Symptom</topic><topic>Hormonal Parameters</topic><topic>Infertility</topic><topic>Original</topic><topic>Ovaries</topic><topic>Polycystic Ovarian Syndrome</topic><topic>Polycystic ovary syndrome</topic><topic>Testosterone</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Afiat, Malihe</creatorcontrib><creatorcontrib>Akbari Lor, Azam</creatorcontrib><creatorcontrib>Najaf Najafi, Mona</creatorcontrib><creatorcontrib>Ghazanfarpour, Masumeh</creatorcontrib><creatorcontrib>Jafarabadi, Mina</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Middle East & Africa Database</collection><collection>ProQuest Central</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>Consumer Health Database (Alumni Edition)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Consumer Health Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>ProQuest - Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>Journal of family & reproductive health</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Afiat, Malihe</au><au>Akbari Lor, Azam</au><au>Najaf Najafi, Mona</au><au>Ghazanfarpour, Masumeh</au><au>Jafarabadi, Mina</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Examining the Effect of Chamomile on Clinical Symptoms and Hormonal Parameters Among Patients With Polycystic Ovarian Syndrome</atitle><jtitle>Journal of family & reproductive health</jtitle><addtitle>J Family Reprod Health</addtitle><date>2022-12-01</date><risdate>2022</risdate><volume>16</volume><issue>4</issue><spage>248</spage><epage>253</epage><pages>248-253</pages><issn>1735-8949</issn><eissn>1735-9392</eissn><abstract>Polycystic ovarian syndrome is the most common cause of infertility and endocrine disorder among women due to anovulation. The aim of the present study is to investigate the effect of chamomile on oligomenorrhea and hirsutism symptoms as well as hormonal parameters among patients suffering from polycystic ovarian syndrome.
The present study is a randomized clinical trial performed on 70 patients with diagnosis of polycystic ovarian syndrome according to Rotterdam criteria referring to the infertility clinic of a university hospital. The patients were randomly assigned into intervention and control groups, with the former receiving two chamomile capsules 500 mg for three months, and the latter receiving two placebo capsules for 3 months. Both groups were evaluated in terms of laboratory parameters (FBS, LDL, and testosterone) on the third day of first and third cycles. The collected data were analyzed by SPSS 20.
The mean age, body mass index, marital status, history of infertility, and pregnancy rate showed no significant difference between the two groups. In the chamomile group, clinical symptoms of hirsutism (p<0.001) and oligomenorrhea (p=0.048) decreased following the treatment, but significant difference was found between the two groups only in hirsutism symptoms (p=0.028). Regarding the parameters of FBS (p=0.06), HDL (p=0.224), cholesterol (p=0.99), triglyceride (p=0.106), testosterone (p=0.894), and LDL (p=0.61), no significant difference was observed between the two groups. Nevertheless, following the treatment, testosterone decreased in both placebo (p=0.005) and chamomile (p=0.001) groups.
overall, the chamomile therapeutic regimen has relatively been able to mitigate the clinical symptoms and testosterone levels in patients suffering from polycystic ovarian syndrome. Use of chamomile plant as a simple, inexpensive, and effective measure can be suggested for improving and treating patients with PCOS after confirmation by further studies.</abstract><cop>Iran</cop><pub>Tehran University of Medical Sciences</pub><pmid>37465426</pmid><doi>10.18502/jfrh.v16i4.11355</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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subjects | Chamomile Clinical Symptom Hormonal Parameters Infertility Original Ovaries Polycystic Ovarian Syndrome Polycystic ovary syndrome Testosterone |
title | Examining the Effect of Chamomile on Clinical Symptoms and Hormonal Parameters Among Patients With Polycystic Ovarian Syndrome |
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