Ultrasound gray scale ratio for differential diagnosis of papillary thyroid microcarcinoma from benign micronodule in patients with Hashimoto’s thyroiditis

• Published in: BMC endocrine disorders 2022-07, Vol.22 (1), p.1-187, Article 187
• Main Authors: Han, Zhijiang, Xie, Lesi, Wei, Peiying, Lei, Zhikai, Ding, Zhongxiang, Zhang, Ming
• Format: Article
• Language: English
• Subjects: Analysis; Calcification; Care and treatment; Diagnosis; Differential diagnosis; Echogenicity; Hashimoto’s thyroiditis; Papillary thyroid microcarcinoma; Statistical analysis; Thyroid; Thyroid gland; Thyroid nodule; Thyroiditis; Ultrasonic imaging; Ultrasound; ultrasound gray scale ratio; Variables
• ISSN: 1472-6823; 1472-6823
• DOI: 10.1186/s12902-022-01028-0

Background To investigate the diagnostic value of ultrasound gray scale ratio (UGSR) in differentiating papillary thyroid microcarcinomas (PTMCs) from benign micronodules (BMNs) in patients with Hashimoto's thyroiditis (HT). Methods The ultrasound images of 285 PTMCs (from 247 patients) and 173 BMNs (from 140 patients) in the HT group, as well as 461 PTMCs (from 417 patients) and 234 BMNs (from 197 patients) in the non-HT group were retrospectively analyzed. The diagnosis of all cases was confirmed by histopathological examinations. The gray scale values of the nodules and surrounding thyroid tissues were measured and subsequently the UGSRs were calculated. Receiver operating characteristic curve analysis was used to determine the area under the curve (AUC), optimal UGSR threshold, sensitivity and specificity in differentiating PTMCs and BMNs in the two groups. Results The UGSR of PTMC and BMN was 0.52 [+ or -] 0.12 and 0.85 [+ or -] 0.24 in the HT group (P < 0.001), and 0.57 [+ or -] 0.13 and 0.87 [+ or -] 0.20 in the non-HT group (P < 0.001), respectively. The difference in PTMC-UGSR was significant between the two groups (P < 0.001), whereas BMN-UGSR did not differ between the two groups (P = 0.416). The AUC, optimal UGSR threshold, sensitivity and specificity of UGSR for differentiating PTMC and BMN in the HT and non-HT group were 0.890 versus 0.901, 0.68 versus 0.72, 91.23% versus 90.67%, and 77.46% versus 82.05%, respectively. Conclusions The USGR of the HT group was lower than that of the non-HT group. Moreover, UGSR exhibited important diagnostic value in differentiating PTMC from BMN in both HT and non-HT groups. Keywords: ultrasound gray scale ratio, Papillary thyroid microcarcinoma, Thyroid nodule, Echogenicity, Hashimoto's thyroiditis