Essential Oils Derived from Cistus Species Activate Mitochondria by Inducing SIRT1 Expression in Human Keratinocytes, Leading to Senescence Inhibition

L. is a genus of dicotyledonous perennial herbaceous plants. species have been commonly used in folk medicine in the Mediterranean region. In the present study, the biological activities of essential oils derived from species , and ) were evaluated. Essential oils derived from and were found to augm...

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Bibliographic Details
Published in:Molecules (Basel, Switzerland) Switzerland), 2022-03, Vol.27 (7), p.2053
Main Authors: Ledrhem, Merieme, Nakamura, Miku, Obitsu, Miyu, Hirae, Kinue, Kameyama, Jun, Bouamama, Hafida, Gadhi, Chemseddoha, Katakura, Yoshinori
Format: Article
Language:English
Subjects:
Aging
anti-aging
Biosynthesis
Cell culture
Cistus
Cistus monspeliensis
DNA damage
essential oil
Essential oils
Folk medicine
Genes
HaCaT
Humans
Keratinocytes
Mitochondria
Mitochondrial DNA
Morphology
Oils & fats
Oils, Volatile - pharmacology
Polyphenols
Senescence
SIRT1
SIRT1 protein
Sirtuin 1 - genetics
Ultraviolet radiation
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Summary:L. is a genus of dicotyledonous perennial herbaceous plants. species have been commonly used in folk medicine in the Mediterranean region. In the present study, the biological activities of essential oils derived from species , and ) were evaluated. Essential oils derived from and were found to augment the expression of SIRT1, an anti-aging gene, in the normal culture of HaCaT cells. Furthermore, these essential oils increased the number and size of mitochondria and augmented their activity. These effects were thought to be caused by the up- and downregulated expression of MITOL and Drp1 in HaCaT cells, respectively, in response to the essential oil treatment. In addition, these essential oils were found to attenuate ultraviolet-B-induced mitochondrial damage and cellular senescence in HaCaT cells. These findings indicate that essential oils derived from and may inhibit skin aging through mitochondrial regulation via SIRT1 activation.
ISSN:1420-3049
1420-3049
DOI:10.3390/molecules27072053