Loading…
Essential Oils Derived from Cistus Species Activate Mitochondria by Inducing SIRT1 Expression in Human Keratinocytes, Leading to Senescence Inhibition
L. is a genus of dicotyledonous perennial herbaceous plants. species have been commonly used in folk medicine in the Mediterranean region. In the present study, the biological activities of essential oils derived from species , and ) were evaluated. Essential oils derived from and were found to augm...
Saved in:
| Published in: | Molecules (Basel, Switzerland) Switzerland), 2022-03, Vol.27 (7), p.2053 |
|---|---|
| Main Authors: | , , , , , , , |
| Format: | Article |
| Language: | English |
| Subjects: | |
| Citations: | Items that this one cites Items that cite this one |
| Online Access: | Get full text |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| cited_by | cdi_FETCH-LOGICAL-c423t-3abddb66b0da98f0d6ca95136e614d53ea944e9d0068b43be6779cb1e2e614d3 |
|---|---|
| cites | cdi_FETCH-LOGICAL-c423t-3abddb66b0da98f0d6ca95136e614d53ea944e9d0068b43be6779cb1e2e614d3 |
| container_end_page | |
| container_issue | 7 |
| container_start_page | 2053 |
| container_title | Molecules (Basel, Switzerland) |
| container_volume | 27 |
| creator | Ledrhem, Merieme Nakamura, Miku Obitsu, Miyu Hirae, Kinue Kameyama, Jun Bouamama, Hafida Gadhi, Chemseddoha Katakura, Yoshinori |
| description | L. is a genus of dicotyledonous perennial herbaceous plants.
species have been commonly used in folk medicine in the Mediterranean region. In the present study, the biological activities of essential oils derived from
species
, and
) were evaluated. Essential oils derived from
and
were found to augment the expression of SIRT1, an anti-aging gene, in the normal culture of HaCaT cells. Furthermore, these essential oils increased the number and size of mitochondria and augmented their activity. These effects were thought to be caused by the up- and downregulated expression of MITOL and Drp1 in HaCaT cells, respectively, in response to the essential oil treatment. In addition, these essential oils were found to attenuate ultraviolet-B-induced mitochondrial damage and cellular senescence in HaCaT cells. These findings indicate that essential oils derived from
and
may inhibit skin aging through mitochondrial regulation via SIRT1 activation. |
| doi_str_mv | 10.3390/molecules27072053 |
| format | article |
| fullrecord | <record><control><sourceid>proquest_doaj_</sourceid><recordid>TN_cdi_doaj_primary_oai_doaj_org_article_f3b84569679c4bc8bdb2ec562e198aae</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><doaj_id>oai_doaj_org_article_f3b84569679c4bc8bdb2ec562e198aae</doaj_id><sourcerecordid>2649591673</sourcerecordid><originalsourceid>FETCH-LOGICAL-c423t-3abddb66b0da98f0d6ca95136e614d53ea944e9d0068b43be6779cb1e2e614d3</originalsourceid><addsrcrecordid>eNplkktvEzEUhUcIRB_wA9ggS2xYNODXeOINUhUCjQiqRLIf-XGTOJqxg-2JyB_h9-ImpWphZcs-59O9R6eq3hD8gTGJP_ahAzN0kGiDG4pr9qw6J5ziEcNcPn90P6suUtpiTAkn9cvqjNUcj3lNz6vf05TAZ6c6dOu6hD5DdHuwaBVDjyYu5SGhxQ6Mg4SuTXZ7lQF9dzmYTfA2OoX0Ac28HYzza7SY_VgSNP21i5CSCx45j26GXnn0DaLKzgdzyJCu0ByUvTPkgBbgIRnwBgpn47TLxfiqerFSXYLX9-dltfwyXU5uRvPbr7PJ9XxkOGV5xJS2VguhsVVyvMJWGCVrwgQIwm3NQEnOQVqMxVhzpkE0jTSaAD0K2GU1O2FtUNt2F12v4qENyrXHhxDXrYrZmQ7aFdMlMSFFAXBtxtpqCqYWFIgcKwWF9enE2g26B1s2ylF1T6BPf7zbtOuwbyUu4xFaAO_vATH8HCDltnclmK5THsKQWiq4rCURDSvSd_9It2GIviR1VGHS1LUoKnJSmRhSirB6GIbg9q5A7X8FKp63j7d4cPxtDPsDADfGyg</addsrcrecordid><sourcetype>Open Website</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2649017556</pqid></control><display><type>article</type><title>Essential Oils Derived from Cistus Species Activate Mitochondria by Inducing SIRT1 Expression in Human Keratinocytes, Leading to Senescence Inhibition</title><source>Publicly Available Content (ProQuest)</source><source>PubMed Central</source><creator>Ledrhem, Merieme ; Nakamura, Miku ; Obitsu, Miyu ; Hirae, Kinue ; Kameyama, Jun ; Bouamama, Hafida ; Gadhi, Chemseddoha ; Katakura, Yoshinori</creator><creatorcontrib>Ledrhem, Merieme ; Nakamura, Miku ; Obitsu, Miyu ; Hirae, Kinue ; Kameyama, Jun ; Bouamama, Hafida ; Gadhi, Chemseddoha ; Katakura, Yoshinori</creatorcontrib><description>L. is a genus of dicotyledonous perennial herbaceous plants.
species have been commonly used in folk medicine in the Mediterranean region. In the present study, the biological activities of essential oils derived from
species
, and
) were evaluated. Essential oils derived from
and
were found to augment the expression of SIRT1, an anti-aging gene, in the normal culture of HaCaT cells. Furthermore, these essential oils increased the number and size of mitochondria and augmented their activity. These effects were thought to be caused by the up- and downregulated expression of MITOL and Drp1 in HaCaT cells, respectively, in response to the essential oil treatment. In addition, these essential oils were found to attenuate ultraviolet-B-induced mitochondrial damage and cellular senescence in HaCaT cells. These findings indicate that essential oils derived from
and
may inhibit skin aging through mitochondrial regulation via SIRT1 activation.</description><identifier>ISSN: 1420-3049</identifier><identifier>EISSN: 1420-3049</identifier><identifier>DOI: 10.3390/molecules27072053</identifier><identifier>PMID: 35408452</identifier><language>eng</language><publisher>Switzerland: MDPI AG</publisher><subject>Aging ; anti-aging ; Biosynthesis ; Cell culture ; Cistus ; Cistus monspeliensis ; DNA damage ; essential oil ; Essential oils ; Folk medicine ; Genes ; HaCaT ; Humans ; Keratinocytes ; Mitochondria ; Mitochondrial DNA ; Morphology ; Oils & fats ; Oils, Volatile - pharmacology ; Polyphenols ; Senescence ; SIRT1 ; SIRT1 protein ; Sirtuin 1 - genetics ; Ultraviolet radiation</subject><ispartof>Molecules (Basel, Switzerland), 2022-03, Vol.27 (7), p.2053</ispartof><rights>2022 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2022 by the authors. 2022</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c423t-3abddb66b0da98f0d6ca95136e614d53ea944e9d0068b43be6779cb1e2e614d3</citedby><cites>FETCH-LOGICAL-c423t-3abddb66b0da98f0d6ca95136e614d53ea944e9d0068b43be6779cb1e2e614d3</cites><orcidid>0000-0003-4524-5362 ; 0000-0002-9678-9602</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.proquest.com/docview/2649017556/fulltextPDF?pq-origsite=primo$$EPDF$$P50$$Gproquest$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.proquest.com/docview/2649017556?pq-origsite=primo$$EHTML$$P50$$Gproquest$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,25753,27924,27925,37012,37013,44590,53791,53793,74998</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/35408452$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ledrhem, Merieme</creatorcontrib><creatorcontrib>Nakamura, Miku</creatorcontrib><creatorcontrib>Obitsu, Miyu</creatorcontrib><creatorcontrib>Hirae, Kinue</creatorcontrib><creatorcontrib>Kameyama, Jun</creatorcontrib><creatorcontrib>Bouamama, Hafida</creatorcontrib><creatorcontrib>Gadhi, Chemseddoha</creatorcontrib><creatorcontrib>Katakura, Yoshinori</creatorcontrib><title>Essential Oils Derived from Cistus Species Activate Mitochondria by Inducing SIRT1 Expression in Human Keratinocytes, Leading to Senescence Inhibition</title><title>Molecules (Basel, Switzerland)</title><addtitle>Molecules</addtitle><description>L. is a genus of dicotyledonous perennial herbaceous plants.
species have been commonly used in folk medicine in the Mediterranean region. In the present study, the biological activities of essential oils derived from
species
, and
) were evaluated. Essential oils derived from
and
were found to augment the expression of SIRT1, an anti-aging gene, in the normal culture of HaCaT cells. Furthermore, these essential oils increased the number and size of mitochondria and augmented their activity. These effects were thought to be caused by the up- and downregulated expression of MITOL and Drp1 in HaCaT cells, respectively, in response to the essential oil treatment. In addition, these essential oils were found to attenuate ultraviolet-B-induced mitochondrial damage and cellular senescence in HaCaT cells. These findings indicate that essential oils derived from
and
may inhibit skin aging through mitochondrial regulation via SIRT1 activation.</description><subject>Aging</subject><subject>anti-aging</subject><subject>Biosynthesis</subject><subject>Cell culture</subject><subject>Cistus</subject><subject>Cistus monspeliensis</subject><subject>DNA damage</subject><subject>essential oil</subject><subject>Essential oils</subject><subject>Folk medicine</subject><subject>Genes</subject><subject>HaCaT</subject><subject>Humans</subject><subject>Keratinocytes</subject><subject>Mitochondria</subject><subject>Mitochondrial DNA</subject><subject>Morphology</subject><subject>Oils & fats</subject><subject>Oils, Volatile - pharmacology</subject><subject>Polyphenols</subject><subject>Senescence</subject><subject>SIRT1</subject><subject>SIRT1 protein</subject><subject>Sirtuin 1 - genetics</subject><subject>Ultraviolet radiation</subject><issn>1420-3049</issn><issn>1420-3049</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>PIMPY</sourceid><sourceid>DOA</sourceid><recordid>eNplkktvEzEUhUcIRB_wA9ggS2xYNODXeOINUhUCjQiqRLIf-XGTOJqxg-2JyB_h9-ImpWphZcs-59O9R6eq3hD8gTGJP_ahAzN0kGiDG4pr9qw6J5ziEcNcPn90P6suUtpiTAkn9cvqjNUcj3lNz6vf05TAZ6c6dOu6hD5DdHuwaBVDjyYu5SGhxQ6Mg4SuTXZ7lQF9dzmYTfA2OoX0Ac28HYzza7SY_VgSNP21i5CSCx45j26GXnn0DaLKzgdzyJCu0ByUvTPkgBbgIRnwBgpn47TLxfiqerFSXYLX9-dltfwyXU5uRvPbr7PJ9XxkOGV5xJS2VguhsVVyvMJWGCVrwgQIwm3NQEnOQVqMxVhzpkE0jTSaAD0K2GU1O2FtUNt2F12v4qENyrXHhxDXrYrZmQ7aFdMlMSFFAXBtxtpqCqYWFIgcKwWF9enE2g26B1s2ylF1T6BPf7zbtOuwbyUu4xFaAO_vATH8HCDltnclmK5THsKQWiq4rCURDSvSd_9It2GIviR1VGHS1LUoKnJSmRhSirB6GIbg9q5A7X8FKp63j7d4cPxtDPsDADfGyg</recordid><startdate>20220322</startdate><enddate>20220322</enddate><creator>Ledrhem, Merieme</creator><creator>Nakamura, Miku</creator><creator>Obitsu, Miyu</creator><creator>Hirae, Kinue</creator><creator>Kameyama, Jun</creator><creator>Bouamama, Hafida</creator><creator>Gadhi, Chemseddoha</creator><creator>Katakura, Yoshinori</creator><general>MDPI AG</general><general>MDPI</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope><orcidid>https://orcid.org/0000-0003-4524-5362</orcidid><orcidid>https://orcid.org/0000-0002-9678-9602</orcidid></search><sort><creationdate>20220322</creationdate><title>Essential Oils Derived from Cistus Species Activate Mitochondria by Inducing SIRT1 Expression in Human Keratinocytes, Leading to Senescence Inhibition</title><author>Ledrhem, Merieme ; Nakamura, Miku ; Obitsu, Miyu ; Hirae, Kinue ; Kameyama, Jun ; Bouamama, Hafida ; Gadhi, Chemseddoha ; Katakura, Yoshinori</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c423t-3abddb66b0da98f0d6ca95136e614d53ea944e9d0068b43be6779cb1e2e614d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Aging</topic><topic>anti-aging</topic><topic>Biosynthesis</topic><topic>Cell culture</topic><topic>Cistus</topic><topic>Cistus monspeliensis</topic><topic>DNA damage</topic><topic>essential oil</topic><topic>Essential oils</topic><topic>Folk medicine</topic><topic>Genes</topic><topic>HaCaT</topic><topic>Humans</topic><topic>Keratinocytes</topic><topic>Mitochondria</topic><topic>Mitochondrial DNA</topic><topic>Morphology</topic><topic>Oils & fats</topic><topic>Oils, Volatile - pharmacology</topic><topic>Polyphenols</topic><topic>Senescence</topic><topic>SIRT1</topic><topic>SIRT1 protein</topic><topic>Sirtuin 1 - genetics</topic><topic>Ultraviolet radiation</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ledrhem, Merieme</creatorcontrib><creatorcontrib>Nakamura, Miku</creatorcontrib><creatorcontrib>Obitsu, Miyu</creatorcontrib><creatorcontrib>Hirae, Kinue</creatorcontrib><creatorcontrib>Kameyama, Jun</creatorcontrib><creatorcontrib>Bouamama, Hafida</creatorcontrib><creatorcontrib>Gadhi, Chemseddoha</creatorcontrib><creatorcontrib>Katakura, Yoshinori</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Publicly Available Content (ProQuest)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>Molecules (Basel, Switzerland)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ledrhem, Merieme</au><au>Nakamura, Miku</au><au>Obitsu, Miyu</au><au>Hirae, Kinue</au><au>Kameyama, Jun</au><au>Bouamama, Hafida</au><au>Gadhi, Chemseddoha</au><au>Katakura, Yoshinori</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Essential Oils Derived from Cistus Species Activate Mitochondria by Inducing SIRT1 Expression in Human Keratinocytes, Leading to Senescence Inhibition</atitle><jtitle>Molecules (Basel, Switzerland)</jtitle><addtitle>Molecules</addtitle><date>2022-03-22</date><risdate>2022</risdate><volume>27</volume><issue>7</issue><spage>2053</spage><pages>2053-</pages><issn>1420-3049</issn><eissn>1420-3049</eissn><abstract>L. is a genus of dicotyledonous perennial herbaceous plants.
species have been commonly used in folk medicine in the Mediterranean region. In the present study, the biological activities of essential oils derived from
species
, and
) were evaluated. Essential oils derived from
and
were found to augment the expression of SIRT1, an anti-aging gene, in the normal culture of HaCaT cells. Furthermore, these essential oils increased the number and size of mitochondria and augmented their activity. These effects were thought to be caused by the up- and downregulated expression of MITOL and Drp1 in HaCaT cells, respectively, in response to the essential oil treatment. In addition, these essential oils were found to attenuate ultraviolet-B-induced mitochondrial damage and cellular senescence in HaCaT cells. These findings indicate that essential oils derived from
and
may inhibit skin aging through mitochondrial regulation via SIRT1 activation.</abstract><cop>Switzerland</cop><pub>MDPI AG</pub><pmid>35408452</pmid><doi>10.3390/molecules27072053</doi><orcidid>https://orcid.org/0000-0003-4524-5362</orcidid><orcidid>https://orcid.org/0000-0002-9678-9602</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1420-3049 |
| ispartof | Molecules (Basel, Switzerland), 2022-03, Vol.27 (7), p.2053 |
| issn | 1420-3049 1420-3049 |
| language | eng |
| recordid | cdi_doaj_primary_oai_doaj_org_article_f3b84569679c4bc8bdb2ec562e198aae |
| source | Publicly Available Content (ProQuest); PubMed Central |
| subjects | Aging anti-aging Biosynthesis Cell culture Cistus Cistus monspeliensis DNA damage essential oil Essential oils Folk medicine Genes HaCaT Humans Keratinocytes Mitochondria Mitochondrial DNA Morphology Oils & fats Oils, Volatile - pharmacology Polyphenols Senescence SIRT1 SIRT1 protein Sirtuin 1 - genetics Ultraviolet radiation |
| title | Essential Oils Derived from Cistus Species Activate Mitochondria by Inducing SIRT1 Expression in Human Keratinocytes, Leading to Senescence Inhibition |
| url | http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-08T01%3A50%3A30IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_doaj_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Essential%20Oils%20Derived%20from%20Cistus%20Species%20Activate%20Mitochondria%20by%20Inducing%20SIRT1%20Expression%20in%20Human%20Keratinocytes,%20Leading%20to%20Senescence%20Inhibition&rft.jtitle=Molecules%20(Basel,%20Switzerland)&rft.au=Ledrhem,%20Merieme&rft.date=2022-03-22&rft.volume=27&rft.issue=7&rft.spage=2053&rft.pages=2053-&rft.issn=1420-3049&rft.eissn=1420-3049&rft_id=info:doi/10.3390/molecules27072053&rft_dat=%3Cproquest_doaj_%3E2649591673%3C/proquest_doaj_%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c423t-3abddb66b0da98f0d6ca95136e614d53ea944e9d0068b43be6779cb1e2e614d3%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=2649017556&rft_id=info:pmid/35408452&rfr_iscdi=true |