IN VITRO RADICAL-SCAVENGING ACTIVITY, TOXICITY AGAINST A. salina , AND NMR PROFILES OF EXTRACTS OF LICHENS COLLECTED FROM BRAZIL AND ANTARCTICA

Extracts of six lichen species collected from Brazil and Antarctica were investigated for their potential toxicity and radical-scavenging properties. The composition of the extracts was investigated using TLC and NMR, leading to identification of atranorin (1), along with salazinic (2), barbatic (3)...

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Bibliographic Details
Published in:Química Nova 2014-01, Vol.37 (6), p.1015-1021
Main Authors: Ravaglia, Luciana M., Gonçalves, Kerolayne, Oyama, Nathália Mitsuko, Coelho, Roberta Gomes, Spielmann, Adriano A., Honda, Neli K.
Format: Article
Language:English
Subjects:
Artemia salina
CHEMISTRY, MULTIDISCIPLINARY
lichens
NMR
phenolic compounds
radical-scavenging potential
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Summary:Extracts of six lichen species collected from Brazil and Antarctica were investigated for their potential toxicity and radical-scavenging properties. The composition of the extracts was investigated using TLC and NMR, leading to identification of atranorin (1), along with salazinic (2), barbatic (3), α-alectoronic (4), α-collatolic (5), cryptochlorophaeic (6), caperatic (7), lobaric (8), and protolichesterinic (9) acids. All acetone extracts were evaluated for their 2,2'-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging ability and subjected to Artemia salina bioassay. The free-radical-scavenging activities of each extract (100 µg) ranged from 8.9 ± 0.1% to 38.7 ± 2.5% and the EC50 values ranged from 0.24 ± 2.10 to 3.54 ± 0.28 mg mL-1, while the toxicity of the extracts against A. salina were low (151.0 to >600 µg mL-1).
ISSN:0100-4042
1678-7064
DOI:10.5935/0100-4042.20140159