Promising drug targets and associated therapeutic interventions in Parkinson's disease

Parkinson's disease (PD) is one of the most debilitating brain diseases. Despite the availability of symptomatic treatments, response towards the health of PD patients remains scarce. To fulfil the medical needs of the PD patients, an efficacious and etiological treatment is required. In this r...

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Bibliographic Details
Published in:Neural regeneration research 2021-09, Vol.16 (9), p.1730-1739
Main Authors: Rai, Sachchida, Singh, Payal, Varshney, Ritu, Chaturvedi, Vivek, Vamanu, Emanuel, Singh, M, Singh, Brijesh
Format: Article
Language:English
Subjects:
dopamine
epigenetics
gene therapies
glutamate receptor
levodopa
molecular chaperones
monoamine oxidase b
mucuna alpha-synuclein
parkinson’s disease
striatum
substantia nigra
Drug targeting
Drug therapy
Nervous system agents
Parkinson's disease
Pharmacology, Experimental
Review
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Summary:Parkinson's disease (PD) is one of the most debilitating brain diseases. Despite the availability of symptomatic treatments, response towards the health of PD patients remains scarce. To fulfil the medical needs of the PD patients, an efficacious and etiological treatment is required. In this review, we have compiled the information covering limitations of current therapeutic options in PD, novel drug targets for PD, and finally, the role of some critical beneficial natural products to control the progression of PD.
ISSN:1673-5374
1876-7958
DOI:10.4103/1673-5374.306066