Tumor Necrosis Factor-α in Temporomandibular Joint Synovial Fluid Predicts Treatment Effects on Pain by Intra-Articular Glucocorticoid Treatment

The aim of this study was to investigate the influence of tumor necrosis factor-alpha (TNF-alpha) in temporomandibular joint (TMJ) synovial fluid and blood on the treatment effect on TMJ pain by intra-articular injection of glucocorticoid in patients with chronic inflammatory TMJ disorders. High pre...

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Bibliographic Details
Published in:Mediators of Inflammation 2006-01, Vol.2006 (6), p.294-300
Main Authors: FREDRIKSSON, Lars, ALSTERGREN, Per, KOPP, Sigvard
Format: Article
Language:English
Subjects:
Arthritis - metabolism
Biological and medical sciences
Facial Pain - drug therapy
Female
General aspects
Glucocorticoids - administration & dosage
Glucocorticoids - therapeutic use
Humans
Injections, Intra-Articular
Medical sciences
Medicin och hälsovetenskap
Middle Aged
Predictive Value of Tests
Research Communication
Synovial Fluid - metabolism
Temporomandibular Joint - metabolism
Temporomandibular Joint Disorders - metabolism
Treatment Outcome
Tumor Necrosis Factor-alpha - analysis
Tumor Necrosis Factor-alpha - metabolism
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Summary:The aim of this study was to investigate the influence of tumor necrosis factor-alpha (TNF-alpha) in temporomandibular joint (TMJ) synovial fluid and blood on the treatment effect on TMJ pain by intra-articular injection of glucocorticoid in patients with chronic inflammatory TMJ disorders. High pretreatment level of TNF-alpha in the synovial fluid was associated with a decrease of TNF-alpha and elimination of pain upon maximal mouth opening. Elimination of this TMJ pain was accordingly associated with decrease in synovial fluid level of TNF-alpha. There was also a significant decrease of C-reactive protein and TMJ resting pain after treatment. In conclusion, this study indicates that presence of TNF-alpha in the synovial fluid predicts a treatment effect of intra-articular injection of glucocorticoid on TMJ movement pain in patients with chronic TMJ inflammatory disorders.
ISSN:0962-9351
1466-1861
DOI:10.1155/MI/2006/59425