The Predictive Role of Parathyroid Hormone for Nonalcoholic Fatty Liver Disease following Bariatric Surgery

Background. Morbid obesity is frequently complicated by chronic liver diseases, including nonalcoholic fatty liver disease (NAFLD), nonalcoholic steatohepatitis (NASH), and fibrosis. Parathyroid hormone (PTH) is found to be elevated in morbid obesity due to the defective hepatic metabolism of vitami...

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Published in:Journal of nutrition and metabolism 2022-02, Vol.2022, p.7319742-6
Main Authors: Jamialahmadi, Tannaz, Nematy, Mohsen, Abdalla, Mohammed, Jangjoo, Ali, Goshayeshi, Ladan, Kroh, Matthew, Moallem, Seyed Adel, Abbasifard, Mitra, Sathyapalan, Thozhukat, Sahebkar, Amirhossein
Format: Article
Language:English
Subjects:
Age
Alanine
Alanine transaminase
Alfacalcidol
Alkaline phosphatase
Biopsy
Body fat
Body mass index
Body weight loss
Calcifediol
Cholesterol
Diabetes
Fatty liver
Females
Fibrosis
Gastric bypass
Gastrointestinal surgery
Heart surgery
Hepatitis
Hormones
Insulin resistance
Laboratories
Liver diseases
Metabolic syndrome
Obesity
Parathyroid
Parathyroid hormone
Patients
Phosphatase
Phosphatases
Physiological aspects
Statistical analysis
Steatosis
Surgery
Type 2 diabetes
Vitamin D
Vitamin deficiency
Weight control
γ-Glutamyltransferase
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Summary:Background. Morbid obesity is frequently complicated by chronic liver diseases, including nonalcoholic fatty liver disease (NAFLD), nonalcoholic steatohepatitis (NASH), and fibrosis. Parathyroid hormone (PTH) is found to be elevated in morbid obesity due to the defective hepatic metabolism of vitamin D. Bariatric surgery is performed to help patients with BMI>40 kg/m2 to effectively lose weight, particularly in patients with obesity who are afflicted with complications such as NAFLD/NASH. Objective. This study aimed to evaluate the PTH level as a predictor of hepatic function in individuals with morbid obesity who have undergone bariatric surgery. Methods. Ninety subjects with morbid obesity referred for Roux en-Y gastric bypass surgery were recruited. After IRB approval, demographic profiles, anthropometric factors, liver biopsy, and laboratory tests were obtained. The two-dimensional shear wave elastography (2D-SWE) technique was applied to assess hepatic stiffness. Results. A significant reduction occurred six months after bariatric surgery in the anthropometric indices p
ISSN:2090-0724
2090-0732
DOI:10.1155/2022/7319742